{"id":"W4393988798","doi":"10.1158/1538-7445.am2024-ct281","title":"Abstract CT281: The phase 3 INTerpath-002 study design: Individualized neoantigen therapy (INT) V940 (mRNA-4157) plus pembrolizumab vs placebo plus pembrolizumab for resected early-stage non-small-cell lung cancer (NSCLC)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"","keywords":"Pembrolizumab; Medicine; non-small cell lung cancer (NSCLC); Lung cancer; Internal medicine; Placebo; Oncology; Stage (stratigraphy); Cancer; Immunotherapy; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003758253,0.002954976,0.002387785,0.000472567,0.0004382659,0.001417396,0.001406662,0.001952338,0.009746053],"category_scores_gemma":[0.001593131,0.0006971576,0.002516614,0.0004409189,0.001168695,0.0009410542,0.0006651027,0.004502445,0.001915364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001353516,"about_ca_system_score_gemma":0.002369017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171473,"about_ca_topic_score_gemma":0.002372906,"domain_scores_codex":[0.9987839,0.0007882233,0.00003610971,0.0001648581,0.00007856248,0.0001483663],"domain_scores_gemma":[0.998897,0.000245151,0.000223822,0.0000947899,0.00007497748,0.0004641871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9609657,0.01159505,0.001173058,0.0005612558,0.00122849,0.00005857817,0.00004700994,0.001018256,0.009530727,0.0002398176,0.002884666,0.01069739],"study_design_scores_gemma":[0.7730615,0.2170381,0.003577387,0.00004306918,0.001045591,0.00006368892,0.00002721792,0.0009992082,0.001777709,0.0002996232,0.00203996,0.0000269475],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.96248,0.003259569,0.00167961,0.001704121,0.0007219033,0.01466252,0.007249223,0.0002476297,0.00799546],"genre_scores_gemma":[0.9401698,0.001868096,0.004934939,0.002567513,0.0009194101,0.02317573,0.007902584,0.0001220811,0.01833992],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.009746053,"threshold_uncertainty_score":0.03260374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1147289221830262,"score_gpt":0.4371691381645255,"score_spread":0.3224402159814993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}