{"id":"W4393988822","doi":"10.1158/1538-7445.am2024-ct284","title":"Abstract CT284: A phase 3 randomized controlled trial of zongertinib (BI 1810631) compared with standard of care in patients with locally advanced or metastatic nonsquamous non-small cell lung cancer harboring <i>HER2</i> tyrosine kinase domain mutations: Beamion LUNG-2","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Medicine; Standard of care; Internal medicine; Oncology; Randomized controlled trial; Lung cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001954164,0.00219609,0.002748569,0.000463388,0.0005548526,0.001325505,0.001232598,0.00188212,0.01571621],"category_scores_gemma":[0.001793976,0.0006325687,0.002453883,0.0004056235,0.00123815,0.001195375,0.0004167114,0.004181745,0.001873977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001221638,"about_ca_system_score_gemma":0.00192799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001708748,"about_ca_topic_score_gemma":0.004100486,"domain_scores_codex":[0.9992014,0.0004616234,0.00004577534,0.0001252717,0.00005662131,0.0001094245],"domain_scores_gemma":[0.9989731,0.0002183154,0.0002698176,0.00006188819,0.0000817013,0.0003951791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9875047,0.004396009,0.0002814671,0.000364448,0.0005633657,0.00001913335,0.00001998372,0.0001820025,0.001450424,0.00005473959,0.0009431532,0.004220507],"study_design_scores_gemma":[0.9636551,0.03460494,0.000717391,0.000016267,0.0002236692,0.00001277683,0.000009011642,0.0002532144,0.0001821848,0.00005267894,0.0002652672,0.000007536455],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709777,0.003998036,0.0007915631,0.001637747,0.0009535616,0.01262279,0.004397055,0.00034754,0.004274],"genre_scores_gemma":[0.9735989,0.001711907,0.001611234,0.002027635,0.0005244576,0.01088,0.003215032,0.00004287956,0.006387848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01571621,"threshold_uncertainty_score":0.05257601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01894318169257741,"score_gpt":0.3876808565188834,"score_spread":0.368737674826306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}