{"id":"W4393988846","doi":"10.1158/1538-7445.am2024-ct253","title":"Abstract CT253: Results from KEYNOTE-B99: Phase 2 study of first-line (1L) pembrolizumab (pembro) plus investigational agents and chemotherapy (chemo) for extensive-stage small-cell lung cancer (ES-SCLC)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre","funders":"","keywords":"Pembrolizumab; Medicine; Investigational Drugs; Chemotherapy; Cancer; Oncology; Stage (stratigraphy); Lung cancer; Internal medicine; Clinical trial; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001410986,0.0004515718,0.0008706787,0.0005633315,0.0004101464,0.0001535045,0.0004251716,0.0001909686,0.0006093323],"category_scores_gemma":[0.000862819,0.0003848267,0.0001686546,0.0009167089,0.0006135133,0.0002070198,0.0003310901,0.001077977,0.000009202373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001641304,"about_ca_system_score_gemma":0.002424304,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01820073,"about_ca_topic_score_gemma":0.003272297,"domain_scores_codex":[0.9947455,0.0001492877,0.0008517352,0.0013761,0.001835736,0.001041629],"domain_scores_gemma":[0.995336,0.001602126,0.0001675791,0.0007815529,0.001568121,0.0005445989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1266909,0.008538365,0.04387761,0.03371822,0.011687,0.001903602,0.08346304,0.00336847,0.2359515,0.0001730299,0.39965,0.05097827],"study_design_scores_gemma":[0.3385479,0.01217242,0.1727022,0.01368966,0.001753619,0.00002571811,0.01601391,0.09445783,0.2123446,0.0009513461,0.1344478,0.002892903],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664893,0.01726114,0.00005060895,0.007535317,0.000339665,0.004988292,0.002874517,0.00009979124,0.0003613433],"genre_scores_gemma":[0.9819529,0.009267235,0.0002040136,0.0003279629,0.001063657,0.00219783,0.0002152971,0.0001467703,0.004624311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2652023,"threshold_uncertainty_score":0.9998603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1650868233839156,"score_gpt":0.4784425243929593,"score_spread":0.3133557010090437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}