{"id":"W4393988984","doi":"10.1158/1538-7445.am2024-ct018","title":"Abstract CT018: TMPRSS2-ERG and RB1 as candidate predictive biomarkers for efficacy in TALAPRO-2: Phase 3 study of talazoparib (TALA) + enzalutamide (ENZA) vs placebo (PBO) + ENZA as first-line (1L) treatment in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Baker Hughes (Canada)","funders":"","keywords":"Enzalutamide; Medicine; TMPRSS2; Placebo; Erg; Oncology; Internal medicine; Prostate cancer; Cancer; Alternative medicine; Pathology; Ophthalmology; Disease; Coronavirus disease 2019 (COVID-19); Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002114871,0.0009669919,0.001167583,0.0003678828,0.0002422846,0.001086139,0.0007442169,0.0006152994,0.005942545],"category_scores_gemma":[0.001663903,0.0002937594,0.001519167,0.0004206257,0.0004542581,0.0005785773,0.0004267476,0.001361986,0.0008904346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008308613,"about_ca_system_score_gemma":0.001086031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007752373,"about_ca_topic_score_gemma":0.002145978,"domain_scores_codex":[0.9992942,0.0003498117,0.00004015525,0.0001436669,0.0001116502,0.00006060666],"domain_scores_gemma":[0.9988807,0.0002513322,0.0003820464,0.00009654006,0.0001214544,0.0002679774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8036485,0.006530799,0.07899947,0.001470539,0.005689358,0.000172017,0.0001519109,0.004124143,0.02280271,0.0002989607,0.006615203,0.06949653],"study_design_scores_gemma":[0.3528265,0.255891,0.3247346,0.0003739743,0.01303466,0.001671382,0.0002380131,0.01225128,0.02109627,0.00106008,0.01662702,0.0001953966],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866318,0.002961534,0.000473069,0.0003680457,0.00006449843,0.0008755288,0.006653454,0.00008249703,0.001889609],"genre_scores_gemma":[0.9838259,0.0006567961,0.0008418466,0.0003645295,0.00009583958,0.0006926149,0.01136901,0.0000226238,0.002130848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005942545,"threshold_uncertainty_score":0.01987982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06675336489293053,"score_gpt":0.4413804102331712,"score_spread":0.3746270453402407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}