{"id":"W4393989035","doi":"10.1158/1538-7445.am2024-ct258","title":"Abstract CT258: Phase II trial of fecal microbiota transplantation in combination with ipilimumab and nivolumab in patients with advanced cutaneous melanoma (FMT-LUMINate trial)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McGill University Health Centre; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Nivolumab; Ipilimumab; Medicine; Fecal bacteriotherapy; Melanoma; Transplantation; Internal medicine; Oncology; Cancer; Immunotherapy; Biology; Antibiotics; Cancer research; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005689429,0.001022877,0.001098327,0.0002707021,0.0003388554,0.0008694212,0.0005415035,0.0008268519,0.007440515],"category_scores_gemma":[0.0004736969,0.0003152021,0.0008395631,0.0002273085,0.000522021,0.0005323741,0.0003061164,0.002484958,0.001212889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008850325,"about_ca_system_score_gemma":0.0007633326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009518148,"about_ca_topic_score_gemma":0.002258962,"domain_scores_codex":[0.9998605,0.00005440523,0.000006269626,0.00003446223,0.00001512209,0.0000290789],"domain_scores_gemma":[0.9998083,0.00002414207,0.00003669903,0.00001403159,0.00001358178,0.0001033006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8092973,0.02062635,0.004795193,0.001642654,0.001442864,0.0003024991,0.0001394832,0.001721502,0.0485777,0.0003900939,0.008118106,0.1029462],"study_design_scores_gemma":[0.7243795,0.2524756,0.01162533,0.000142982,0.0006758358,0.0003244528,0.00006429051,0.001501182,0.003801258,0.000240002,0.004740956,0.00002867147],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863546,0.0042445,0.0004808926,0.0008598363,0.0002607441,0.001470054,0.001737938,0.000172159,0.0044192],"genre_scores_gemma":[0.9857107,0.001716202,0.0009588172,0.0008699744,0.0001855653,0.00167164,0.00263462,0.00002816547,0.006224262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007440515,"threshold_uncertainty_score":0.02489096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02563909890897978,"score_gpt":0.3580182507507146,"score_spread":0.3323791518417348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}