{"id":"W4393989103","doi":"10.1158/1538-7445.am2024-ct100","title":"Abstract CT100: Safety and efficacy of AZD8853, an anti-growth and differentiation factor 15 (GDF15) antibody, in patients (pts) with advanced/metastatic solid tumors: First-in-human study","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Princess Margaret Cancer Centre","funders":"","keywords":"GDF15; Medicine; Antibody; Oncology; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004230663,0.0001805447,0.0004232465,0.0006143466,0.00009435954,0.00005002375,0.00009092547,0.00006892916,0.00006666355],"category_scores_gemma":[0.00008109774,0.000127195,0.00002585268,0.000652006,0.0002148752,0.0002091346,0.00006765263,0.0005353325,0.00000174962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001398848,"about_ca_system_score_gemma":0.0001399358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009010394,"about_ca_topic_score_gemma":0.0006005831,"domain_scores_codex":[0.997952,0.0001251131,0.0004158612,0.0004987696,0.0006079639,0.0004002327],"domain_scores_gemma":[0.9992408,0.0001757938,0.00005914154,0.0002122927,0.0001402789,0.0001717419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001377529,0.001398741,0.9695235,0.001337606,0.0001503482,0.0001571784,0.002793843,0.00002380853,0.0165178,0.00001178845,0.00001313633,0.006694749],"study_design_scores_gemma":[0.0065095,0.002103593,0.9867704,0.001866614,0.00003813323,0.000002973643,0.0007221377,0.0002123679,0.001610582,0.00001745375,0.00001171715,0.000134519],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971415,0.001092446,0.000003159261,0.0001413131,0.00005142075,0.00141824,0.00003635136,0.00002175299,0.00009384876],"genre_scores_gemma":[0.999023,0.0007708137,0.00001504487,0.000005306835,0.00002466893,0.00002831019,0.00006089713,0.00003357103,0.0000383826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01724694,"threshold_uncertainty_score":0.5186861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0308401320126218,"score_gpt":0.3957942137866368,"score_spread":0.3649540817740149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}