{"id":"W4393989103","doi":"10.1158/1538-7445.am2024-ct100","title":"Abstract CT100: Safety and efficacy of AZD8853, an anti-growth and differentiation factor 15 (GDF15) antibody, in patients (pts) with advanced/metastatic solid tumors: First-in-human study","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Princess Margaret Cancer Centre","funders":"","keywords":"GDF15; Medicine; Antibody; Oncology; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006499276,0.000949043,0.001272852,0.0002614569,0.000286891,0.0008221281,0.0005229329,0.0008116721,0.003792517],"category_scores_gemma":[0.0007687884,0.0003592464,0.0008191812,0.0003181873,0.0006761363,0.0005594877,0.000219141,0.002148673,0.001104882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001145893,"about_ca_system_score_gemma":0.001061907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001070014,"about_ca_topic_score_gemma":0.001576528,"domain_scores_codex":[0.9997687,0.0001011432,0.00001491115,0.00004833864,0.00003337652,0.00003352742],"domain_scores_gemma":[0.9994799,0.0000890308,0.0001261072,0.00004887268,0.00003814486,0.0002179879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6818597,0.026147,0.0174094,0.001297654,0.001797289,0.0006318219,0.00026139,0.00307248,0.1075903,0.0002585098,0.006275226,0.1533992],"study_design_scores_gemma":[0.2532742,0.6686655,0.04467581,0.0001066217,0.001431502,0.001335146,0.00007118177,0.002589176,0.01955588,0.0002162354,0.008029914,0.00004873118],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921736,0.003016752,0.0005137554,0.0002213518,0.00005497432,0.000627202,0.001475236,0.0001109652,0.001806266],"genre_scores_gemma":[0.9945461,0.00109636,0.0004045031,0.0002945694,0.00006155502,0.0003142225,0.001694232,0.00001734622,0.001571091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003792517,"threshold_uncertainty_score":0.01268727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0308401320126218,"score_gpt":0.3957942137866368,"score_spread":0.3649540817740149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}