{"id":"W4393989120","doi":"10.1158/1538-7445.am2024-ct133","title":"Abstract CT133: A phase 1b multicenter study of anti-TIM3 (S095018/Sym023) in combination with anti-PD1 (Sym021) in patients with advanced/metastatic recurrent biliary tract cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Biliary tract cancer; Medicine; Cancer; Biliary tract; Internal medicine; Oncology; Gastroenterology; Gemcitabine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001385933,0.002033325,0.001748432,0.0005626589,0.0004637484,0.0008437138,0.0008373453,0.001074036,0.004676191],"category_scores_gemma":[0.0005786405,0.0006718891,0.001323837,0.0005503875,0.001016705,0.0007196469,0.000415333,0.002717119,0.00130835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001428299,"about_ca_system_score_gemma":0.002351857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002819587,"about_ca_topic_score_gemma":0.007174983,"domain_scores_codex":[0.9995605,0.0002242919,0.00001895421,0.00006360382,0.00004223365,0.0000903796],"domain_scores_gemma":[0.9995988,0.00003190817,0.00005956377,0.00002564864,0.00002841128,0.0002556799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6507266,0.07278895,0.01050814,0.001328403,0.001931365,0.0005445466,0.0004965007,0.005211688,0.1396684,0.0005794601,0.01160582,0.1046102],"study_design_scores_gemma":[0.3980454,0.5712791,0.01528902,0.00004847938,0.0005831601,0.0004485857,0.00008906014,0.001754697,0.008447764,0.0001418716,0.003823457,0.00004942952],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907749,0.001472481,0.0005594523,0.0005867927,0.0001030512,0.002498626,0.001668866,0.0001930519,0.002142596],"genre_scores_gemma":[0.9857901,0.001321809,0.001868253,0.0006865721,0.0001246978,0.002439673,0.003844662,0.00004755753,0.003876738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004676191,"threshold_uncertainty_score":0.01564342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06163239915122215,"score_gpt":0.4186272363775294,"score_spread":0.3569948372263073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}