{"id":"W4393989319","doi":"10.1158/1538-7445.am2024-lb181","title":"Abstract LB181: First disclosure of XRD-0394, a novel dual ATM/DNA-PK inhibitor, that potently radiosensitizes and potentiates PARP and topoisomerase inhibitors","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"PARP inhibitor; Cancer research; Topoisomerase; DNA; Dual (grammatical number); Chemistry; Poly ADP ribose polymerase; Pharmacology; Medicine; Polymerase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005180918,0.001022932,0.0003388442,0.0004313707,0.0004147905,0.0008762972,0.001077912,0.001413601,0.01355506],"category_scores_gemma":[0.0006188001,0.0003311662,0.0002709877,0.0004153783,0.0002868593,0.000396572,0.0004820746,0.0009560899,0.005178418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009336994,"about_ca_system_score_gemma":0.001275168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009073465,"about_ca_topic_score_gemma":0.0009209197,"domain_scores_codex":[0.9996595,0.00005014919,0.00003680485,0.00003864004,0.0001454681,0.00006938465],"domain_scores_gemma":[0.9996661,0.00004223013,0.0001003419,0.00002534053,0.00008138853,0.00008455089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002847275,0.001426396,0.003134179,0.001558131,0.0001504836,0.005499339,0.0001696504,0.001712684,0.4046113,0.01932591,0.2740399,0.2855247],"study_design_scores_gemma":[0.0004399006,0.001805286,0.00260483,0.0001095767,0.00007004743,0.003390045,0.00003287895,0.001592142,0.1463733,0.000674794,0.842886,0.00002119952],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.2729139,0.1132548,0.03339657,0.0342798,0.01320752,0.004658843,0.02401779,0.002213908,0.5020568],"genre_scores_gemma":[0.5148383,0.03593405,0.01065762,0.004409955,0.006620843,0.001112577,0.0174925,0.0001096669,0.4088245],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.01355506,"threshold_uncertainty_score":0.04534614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07114726092234676,"score_gpt":0.3767257946361513,"score_spread":0.3055785337138046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}