{"id":"W4393989580","doi":"10.1158/1538-7445.am2024-ct212","title":"Abstract CT212: Phase Ib/II, global, open-label, randomized evaluation of atezolizumab (atezo) + etrumadenant (etruma) + chemotherapy (chemo) vs chemo alone in MORPHEUS-PDAC","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Atezolizumab; Medicine; Chemotherapy; Oncology; Internal medicine; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001451378,0.001799842,0.001853241,0.0004507431,0.0004043512,0.0009813349,0.0009301353,0.001233579,0.007632766],"category_scores_gemma":[0.0008608678,0.0006132994,0.001130226,0.0005625249,0.001147734,0.0008773228,0.0004234399,0.002707401,0.001249868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009488686,"about_ca_system_score_gemma":0.001383768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117742,"about_ca_topic_score_gemma":0.003627477,"domain_scores_codex":[0.99961,0.0002356354,0.00001905992,0.00005751707,0.00002582208,0.00005196056],"domain_scores_gemma":[0.9994795,0.00008253284,0.0001277768,0.00004262265,0.0000345505,0.0002331397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.956239,0.01249271,0.001193374,0.0005155455,0.0005417506,0.00004791243,0.00004580154,0.0007126439,0.009359669,0.0001026938,0.001528442,0.01722026],"study_design_scores_gemma":[0.8601806,0.1345,0.00267428,0.00002605718,0.0002786782,0.00006884758,0.00002390223,0.0003351844,0.0008070219,0.00007591565,0.001016616,0.00001295502],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849175,0.002467812,0.0005846619,0.000563283,0.0001835542,0.005190847,0.002872898,0.0001852742,0.003034309],"genre_scores_gemma":[0.9781309,0.00228903,0.001862668,0.00121963,0.0003295289,0.006015053,0.004124233,0.00005065593,0.00597827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007632766,"threshold_uncertainty_score":0.02553415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2581388575970844,"score_gpt":0.5709261974956136,"score_spread":0.3127873398985291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}