{"id":"W4393989657","doi":"10.1158/1538-7445.am2024-ct146","title":"Abstract CT146: AZD0466 in patients with advanced non-Hodgkin lymphoma: Efficacy and safety in an open-label phase 1 trial","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Medicine; Open label; Hodgkin lymphoma; Lymphoma; Oncology; Internal medicine; Phases of clinical research; Clinical trial; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001568683,0.001168201,0.001759919,0.0003890125,0.0003436268,0.0009825905,0.0007371865,0.001235507,0.004571642],"category_scores_gemma":[0.0009556026,0.0003764042,0.001039226,0.0004634422,0.0007014066,0.0007464984,0.0003236546,0.002513805,0.0009859293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006601646,"about_ca_system_score_gemma":0.001075798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004037332,"about_ca_topic_score_gemma":0.001196341,"domain_scores_codex":[0.9995093,0.0002900719,0.00002755046,0.00006143977,0.00004712773,0.00006447534],"domain_scores_gemma":[0.9993852,0.0001007591,0.0001305257,0.00003516666,0.0000445183,0.0003036468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8539173,0.03142966,0.005332937,0.00113235,0.0009462738,0.0004290576,0.0001979865,0.00158919,0.02975863,0.0002798077,0.003807397,0.07117932],"study_design_scores_gemma":[0.6729767,0.3112521,0.008266433,0.00005905359,0.0003479379,0.0003550125,0.00003886637,0.001073108,0.002446638,0.0001872414,0.002967013,0.00002984692],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868308,0.004355177,0.0006269367,0.0005392557,0.0001750181,0.003290311,0.001980689,0.0001474448,0.002054307],"genre_scores_gemma":[0.9832628,0.002966042,0.001929177,0.001002415,0.0003744348,0.003455443,0.003270171,0.00002911554,0.003710408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004571642,"threshold_uncertainty_score":0.01529366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08726353258399154,"score_gpt":0.4700582384299437,"score_spread":0.3827947058459521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}