{"id":"W4393989857","doi":"10.1158/1538-7445.am2024-lb107","title":"Abstract LB107: Association of circulating free DNA (cfDNA) maximum variant allele frequency (mVAF) levels with clinical outcomes in patients (pts) with metastatic nonsquamous non-small cell lung cancer (NSCLC) treated with pembrolizumab (pembro) + chemotherapy (chemo) in the phase 2 KEYNOTE-782 trial","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Queen's University","funders":"","keywords":"Medicine; Pembrolizumab; Lung cancer; Oncology; Internal medicine; non-small cell lung cancer (NSCLC); Circulating tumor DNA; Circulating tumor cell; Cancer; Immunotherapy; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001147121,0.0004091725,0.0006612193,0.0001468144,0.0001489999,0.0005816147,0.0004181727,0.0005026433,0.003858034],"category_scores_gemma":[0.00155533,0.0001845261,0.000519516,0.0002492121,0.0002342118,0.000548497,0.0003337108,0.001028525,0.0006141648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003464385,"about_ca_system_score_gemma":0.0003682793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004281762,"about_ca_topic_score_gemma":0.0008114011,"domain_scores_codex":[0.9995824,0.0002352366,0.00002356274,0.00008306085,0.00004639166,0.00002941393],"domain_scores_gemma":[0.9992341,0.0002611421,0.0002425018,0.00006505364,0.00004425599,0.0001529454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6994303,0.003763864,0.2145293,0.0008916766,0.002811245,0.0001408685,0.00008741569,0.001684173,0.02386627,0.0002861533,0.006755048,0.04575365],"study_design_scores_gemma":[0.149007,0.1703262,0.6481366,0.0001817868,0.004264237,0.0008519783,0.0001463497,0.006596651,0.01074853,0.0008917853,0.008761987,0.00008692441],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930783,0.00139632,0.0003360977,0.0002865352,0.00003341182,0.0001684881,0.003228497,0.00005443301,0.001418063],"genre_scores_gemma":[0.9925253,0.0002584138,0.0005622389,0.000215906,0.00008215079,0.0002055276,0.00507034,0.00001377345,0.001066443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003858034,"threshold_uncertainty_score":0.01290637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04519618720182673,"score_gpt":0.3768658475747349,"score_spread":0.3316696603729082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}