{"id":"W4393990509","doi":"10.1136/bmjopen-2023-072159","title":"Hepatopancreaticobiliary Resection Arginine Immunomodulation (PRIMe) trial: protocol for a randomised phase II trial of the impact of perioperative immunomodulation on immune function following resection for hepatopancreaticobiliary malignancy","year":2024,"lang":"en","type":"article","venue":"BMJ Open","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Hospital; Institute for Clinical Evaluative Sciences; Sunnybrook Health Science Centre; Ottawa Hospital; University of Ottawa; University of Toronto","funders":"Sunnybrook Research Institute","keywords":"Medicine; Perioperative; Immune system; Malignancy; Randomized controlled trial; Resection; Clinical trial; Immunotherapy; Surgery; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01009267,0.00350594,0.004708319,0.0005531328,0.001503229,0.002203595,0.001863271,0.004327644,0.03130815],"category_scores_gemma":[0.009104981,0.001402975,0.002086573,0.0009174821,0.00233561,0.002088562,0.0009387853,0.003717621,0.005015995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001896243,"about_ca_system_score_gemma":0.005226278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009244278,"about_ca_topic_score_gemma":0.002029904,"domain_scores_codex":[0.9953606,0.002806783,0.0003360852,0.0006087914,0.0003554934,0.0005323524],"domain_scores_gemma":[0.9966114,0.0007538217,0.0008936236,0.0005112322,0.0003849407,0.000844983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9840984,0.003373207,0.0003596355,0.001910918,0.0005100633,0.00006393745,0.00008183864,0.0002441813,0.001292339,0.0005600153,0.002968504,0.00453705],"study_design_scores_gemma":[0.9731387,0.02039239,0.0007696482,0.0001983705,0.00024472,0.00002931795,0.00002438507,0.0002772459,0.0002442167,0.0005807638,0.004081368,0.00001877412],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.08933261,0.00258849,0.003299284,0.00189067,0.001877814,0.8887702,0.005863263,0.0002720313,0.006105536],"genre_scores_gemma":[0.08633563,0.001031236,0.004589581,0.001321378,0.0005647023,0.8998648,0.001502939,0.00003172607,0.004757999],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03130815,"threshold_uncertainty_score":0.1047361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07271180202535599,"score_gpt":0.4495803094029732,"score_spread":0.3768685073776172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}