{"id":"W4393992789","doi":"10.1002/glia.24531","title":"Chronically activated microglia in <scp>ALS</scp> gradually lose their immune functions and develop unconventional proteome","year":2024,"lang":"en","type":"article","venue":"Glia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Fondation Brain Canada; ALS Society of Canada","keywords":"Microglia; Biology; Immune system; Proteome; Neuroinflammation; Innate immune system; Downregulation and upregulation; Immunology; Cell biology; Neuroscience; Inflammation; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001336902,0.0003629487,0.0004282282,0.0003866247,0.0002804459,0.0004108985,0.0001476177,0.0003848161,0.001639203],"category_scores_gemma":[0.0001372219,0.0001388982,0.0003012912,0.0002605118,0.0003230599,0.0002538479,0.0002761532,0.0008626534,0.0007471314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002564848,"about_ca_system_score_gemma":0.0002142721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008464261,"about_ca_topic_score_gemma":0.001016605,"domain_scores_codex":[0.9997682,0.00001568984,0.00002689059,0.00006498174,0.00007298453,0.00005129847],"domain_scores_gemma":[0.9997941,0.00001990163,0.00005927945,0.00002510301,0.00003995205,0.0000618107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001734675,0.00002513717,0.0008551595,0.00002715204,0.0000107645,0.0003468283,0.00004225141,0.0000235836,0.9973978,0.0000392989,0.00009074647,0.0009677532],"study_design_scores_gemma":[0.00003500165,0.0009015593,0.1223068,0.00003591242,0.00007873561,0.006743962,0.0003946857,0.0009352069,0.8610033,0.0004182408,0.007118651,0.00002790005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995442,0.0008259148,0.001342851,0.0001129689,0.00002955009,0.0000278639,0.001354,0.0000950003,0.0007698461],"genre_scores_gemma":[0.989457,0.0007145529,0.001645075,0.0001536551,0.00002869948,0.0001087193,0.002909085,0.00005025564,0.004933082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001639203,"threshold_uncertainty_score":0.005483747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0228573321934637,"score_gpt":0.2802929589821129,"score_spread":0.2574356267886492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}