{"id":"W4393995174","doi":"10.1016/j.cell.2024.03.015","title":"Human iPSC 4R tauopathy model uncovers modifiers of tau propagation","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Aging; Weill Cornell Medical College; Fondation Brain Canada; JPB Foundation; National Institutes of Health; Tau Consortium; Memorial Sloan-Kettering Cancer Center","keywords":"Tauopathy; Biology; Tau protein; Progressive supranuclear palsy; Tangle; Induced pluripotent stem cell; Neuroscience; Cell biology; Neurodegeneration; Alzheimer's disease; Gene; Genetics; Disease; Embryonic stem cell; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006972164,0.0000928261,0.0001300622,0.00009799366,0.00004054211,0.00001416843,0.00004433142,0.0000452319,0.00008718756],"category_scores_gemma":[0.000007410124,0.0000732699,0.00009170063,0.0001323762,0.00006173183,0.00007936333,0.00002086792,0.00009937239,0.0001335693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000850022,"about_ca_system_score_gemma":0.000259544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003258723,"about_ca_topic_score_gemma":0.000001251065,"domain_scores_codex":[0.9991973,0.00001623012,0.0001277919,0.0001905754,0.0002882774,0.0001798118],"domain_scores_gemma":[0.9995499,0.00001113098,0.00002323856,0.0001867254,0.0000565726,0.0001724934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.003946357,0.01683531,0.04732249,0.02433255,0.03504856,0.008795124,0.0155386,0.03327454,0.5305541,0.02220045,0.229777,0.03237493],"study_design_scores_gemma":[0.01069101,0.003190484,0.005649365,0.001276076,0.004115731,0.0000367198,0.001605903,0.4851972,0.4754443,0.01036688,0.001518511,0.0009077238],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682916,0.003427657,0.0003915295,0.0001046013,0.00006066042,0.0004579944,0.00003975723,0.00007459886,0.02715155],"genre_scores_gemma":[0.998193,0.00004229896,0.0001493786,0.00002856333,0.00004180583,0.0000239687,0.00008045703,0.00002012153,0.001420439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4519227,"threshold_uncertainty_score":0.298786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03338473392487547,"score_gpt":0.3150618310480672,"score_spread":0.2816770971231917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}