{"id":"W4393995174","doi":"10.1016/j.cell.2024.03.015","title":"Human iPSC 4R tauopathy model uncovers modifiers of tau propagation","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Aging; Weill Cornell Medical College; Fondation Brain Canada; JPB Foundation; National Institutes of Health; Tau Consortium; Memorial Sloan-Kettering Cancer Center","keywords":"Tauopathy; Biology; Tau protein; Progressive supranuclear palsy; Tangle; Induced pluripotent stem cell; Neuroscience; Cell biology; Neurodegeneration; Alzheimer's disease; Gene; Genetics; Disease; Embryonic stem cell; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004345539,0.0007125665,0.0004832314,0.001066398,0.0005006681,0.0008145366,0.0006034367,0.001008361,0.006460764],"category_scores_gemma":[0.000331594,0.000329702,0.0009536008,0.0003744847,0.0005288097,0.0005739078,0.0004588722,0.00170514,0.002283239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004879367,"about_ca_system_score_gemma":0.0004434868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001258023,"about_ca_topic_score_gemma":0.001167643,"domain_scores_codex":[0.9997098,0.00003041504,0.00003358381,0.00008969572,0.00008529703,0.00005117732],"domain_scores_gemma":[0.9997094,0.00006157444,0.00007765477,0.0000849553,0.0000358669,0.00003040996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002285005,0.00007596106,0.0004379459,0.00007083706,0.00002674229,0.0004220939,0.00005550672,0.000231134,0.9945362,0.0006792367,0.0003555173,0.002880325],"study_design_scores_gemma":[0.00002811186,0.0001439733,0.003133898,0.00002746594,0.0001257222,0.0008177815,0.00006831055,0.001310857,0.9874373,0.0004285008,0.006464004,0.00001398058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9499815,0.003157394,0.02431952,0.0008047515,0.0004637126,0.0001534511,0.007437026,0.001368065,0.01231471],"genre_scores_gemma":[0.9669845,0.002411037,0.009828971,0.0003819795,0.00005291295,0.0001760322,0.00448961,0.0003568866,0.01531796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006460764,"threshold_uncertainty_score":0.02161336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03338473392487547,"score_gpt":0.3150618310480672,"score_spread":0.2816770971231917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}