{"id":"W4394008668","doi":"10.1016/j.modpat.2024.100489","title":"Somatic Tumor Testing in Prostate Cancer: Experience of a Tertiary Care Center Including Pathologist-Driven Reflex Testing of Localized Tumors at Diagnosis","year":2024,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Janssen Canada; AstraZeneca Canada","keywords":"Prostate cancer; Medicine; Genetic testing; Cancer; Oncology; Pathology; Internal medicine; Primary tumor; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002159381,0.0002312846,0.0006044321,0.0003190831,0.0000709977,0.00001077069,0.0001467635,0.00007826013,0.0000288639],"category_scores_gemma":[0.0004716273,0.0001800087,0.00008434978,0.0005080011,0.0003898761,0.0000915238,0.0003255689,0.0002636958,0.000004237652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004711955,"about_ca_system_score_gemma":0.0002937111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003761366,"about_ca_topic_score_gemma":0.00009377005,"domain_scores_codex":[0.9978868,0.0001495929,0.0006327747,0.0005498063,0.0002715231,0.0005094623],"domain_scores_gemma":[0.9988893,0.0003670709,0.0001641096,0.0003046907,0.0001818101,0.00009303505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001539917,0.0001205802,0.8135866,0.001910555,0.0000210019,0.005065022,0.01757088,0.0001662925,0.1405295,0.000001919859,0.000009054373,0.02086456],"study_design_scores_gemma":[0.007730533,0.001988481,0.5839391,0.01772299,0.0002316421,0.001923698,0.00546817,0.06075251,0.3187472,0.0006829579,0.0000880052,0.000724629],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896644,0.008702933,0.00004554388,0.0002490199,0.00009941905,0.0007981702,0.0001055913,0.00008963263,0.0002453214],"genre_scores_gemma":[0.9959376,0.0002130243,0.002796419,0.00006873696,0.0000321195,0.0008000595,0.00003376688,0.00004420197,0.00007409637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2296475,"threshold_uncertainty_score":0.734054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07643797035752352,"score_gpt":0.3738260665509759,"score_spread":0.2973880961934524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}