{"id":"W4394010494","doi":"10.1007/s00401-024-02707-z","title":"Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases","year":2024,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Università degli Studi di Perugia; Amsterdam University Medical Centers; Institute of Genetics; Prothena","keywords":"TFEB; Dementia with Lewy bodies; Lewy body; Alpha-synuclein; Dopaminergic; Parkinson's disease; Basic helix-loop-helix leucine zipper transcription factors; Biology; Cell biology; Subcellular localization; Pathology; Neuroscience; Dopamine; Cytoplasm; Dementia; Transcription factor; Medicine; Disease; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225871,0.0002673411,0.0002529942,0.000711227,0.0002388535,0.0002759839,0.00008334441,0.0003057454,0.0007907362],"category_scores_gemma":[0.0002606383,0.0001697016,0.000115051,0.0002471636,0.0002850705,0.0001644463,0.0001849711,0.0001557489,0.0001700049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001505034,"about_ca_system_score_gemma":0.00006909692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001926181,"about_ca_topic_score_gemma":0.001982985,"domain_scores_codex":[0.9999285,0.000008220656,0.00001037992,0.00003312625,0.00000979593,0.00001005298],"domain_scores_gemma":[0.999895,0.00001208668,0.00004186746,0.000008634568,0.00001556054,0.00002682412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00283052,0.0001160444,0.4200027,0.0001481049,0.0001568283,0.003597286,0.001338941,0.00008987618,0.5614437,0.00007833041,0.0001690185,0.01002866],"study_design_scores_gemma":[0.00002026493,0.0002256442,0.9859744,0.00000764319,0.00005007508,0.005878157,0.000398667,0.0001936089,0.006878455,0.00007362195,0.0002926102,0.000006755727],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993216,0.0003606984,0.0001226173,0.000006362049,0.000001407033,0.000002083058,0.00007463559,0.000006783303,0.0001037452],"genre_scores_gemma":[0.9993037,0.0001388195,0.0001803993,0.00001010649,0.000002366442,0.00000440019,0.0001361323,0.000004603468,0.0002194409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001926181,"threshold_uncertainty_score":0.003829956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079949221917316,"score_gpt":0.2378371337273788,"score_spread":0.2270376415082057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}