{"id":"W4394014558","doi":"10.1021/acs.jafc.4c01052","title":"Bioavailability and Metabolism of Bioactive Peptide IRW with Angiotensin-Converting Enzyme 2 (ACE2) Upregulatory Activity in Spontaneously Hypertensive Rats","year":2024,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Metabolite; Bioavailability; Kynurenine; Blood pressure; Pharmacology; Chemistry; Oral administration; Pharmacokinetics; Active metabolite; Kynurenine pathway; Metabolism; Angiotensin II; Renin–angiotensin system; Angiotensin-converting enzyme; Tryptophan; Endocrinology; Biochemistry; Medicine; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265583,0.0003374847,0.000375837,0.0002620811,0.0001181151,0.0001598839,0.0001094197,0.0002376051,0.0007760437],"category_scores_gemma":[0.0001380744,0.000160629,0.0002704039,0.0001101666,0.0001585441,0.0002452098,0.0001072344,0.0006123701,0.00014643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001876337,"about_ca_system_score_gemma":0.0001824061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007830451,"about_ca_topic_score_gemma":0.0008909727,"domain_scores_codex":[0.9999372,0.000008478002,0.000004837776,0.00001521882,0.00001351609,0.00002074439],"domain_scores_gemma":[0.9998802,0.00001007082,0.00004897681,0.00001182872,0.00001417042,0.00003466173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00173861,0.0002169294,0.0009187367,0.00003495905,0.00001963565,0.00006348658,0.0000269423,0.00005615054,0.9938899,0.00003073001,0.00004311962,0.002960758],"study_design_scores_gemma":[0.0001260646,0.009187391,0.03020106,0.00001173386,0.0001106138,0.0002483681,0.0001191501,0.001566151,0.9569731,0.00009482262,0.001342586,0.00001889008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985607,0.0003960927,0.0006645361,0.00003406567,0.000009642344,0.00000894083,0.0001315502,0.0000180973,0.0001762755],"genre_scores_gemma":[0.995482,0.0006711455,0.001534084,0.00005197428,0.00001358704,0.00004153182,0.0003165626,0.00001321084,0.001875945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007830451,"threshold_uncertainty_score":0.00259614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031101701455549,"score_gpt":0.1989662540358246,"score_spread":0.1886552370212691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}