{"id":"W4394014785","doi":"10.1038/s41541-024-00862-8","title":"Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines","year":2024,"lang":"en","type":"article","venue":"npj Vaccines","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; Basic Energy Sciences; National Institute of Allergy and Infectious Diseases; International AIDS Vaccine Initiative; National Institute of General Medical Sciences; University of California, San Francisco; Bill and Melinda Gates Foundation; Office of Science; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Commission; U.S. Department of Energy; European Molecular Biology Organization; National Institutes of Health; Aids Fonds","keywords":"Trimer; Virology; Gp41; Hemagglutinin (influenza); Glycoprotein; Biology; Recombinant DNA; Antibody; Chemistry; Computational biology; Genetics; Virus; Gene; Dimer; Epitope","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002536384,0.0003333477,0.0002211592,0.0004147846,0.0001683045,0.0002513813,0.0002341035,0.0005569124,0.001248931],"category_scores_gemma":[0.0001544068,0.0001811288,0.0003921231,0.0002024131,0.0001523187,0.0003070137,0.0002641903,0.0007346513,0.0005411671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003056279,"about_ca_system_score_gemma":0.0002048113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001070716,"about_ca_topic_score_gemma":0.0002983101,"domain_scores_codex":[0.9998446,0.00003907822,0.00001069982,0.00002259199,0.00005638501,0.0000266287],"domain_scores_gemma":[0.9999286,0.000008746831,0.00002640916,0.000008953052,0.000009309888,0.00001792848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006085514,0.00006377053,0.0001066838,0.00006911962,0.000007921758,0.00004664502,0.00002162063,0.0005144512,0.991066,0.000636665,0.000164551,0.007241695],"study_design_scores_gemma":[0.00003206907,0.001391653,0.0009237721,0.00001970461,0.00002942206,0.0004726764,0.00002688435,0.002805417,0.9839029,0.0005316787,0.009850783,0.00001309713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8944404,0.009188021,0.08820691,0.0004793393,0.0002933758,0.0005517143,0.0005529237,0.0003816458,0.005905797],"genre_scores_gemma":[0.9051213,0.003785613,0.08365212,0.0003547924,0.00006679051,0.0003369743,0.0006104701,0.00005972133,0.006012098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001248931,"threshold_uncertainty_score":0.004178047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253234671378306,"score_gpt":0.2973749449744185,"score_spread":0.2748425982606354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}