{"id":"W4394014785","doi":"10.1038/s41541-024-00862-8","title":"Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines","year":2024,"lang":"en","type":"article","venue":"npj Vaccines","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; Basic Energy Sciences; National Institute of Allergy and Infectious Diseases; International AIDS Vaccine Initiative; National Institute of General Medical Sciences; University of California, San Francisco; Bill and Melinda Gates Foundation; Office of Science; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Commission; U.S. Department of Energy; European Molecular Biology Organization; National Institutes of Health; Aids Fonds","keywords":"Trimer; Virology; Gp41; Hemagglutinin (influenza); Glycoprotein; Biology; Recombinant DNA; Antibody; Chemistry; Computational biology; Genetics; Virus; Gene; Dimer; Epitope","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001979868,0.000245168,0.0003220057,0.0002097581,0.0002478925,0.00007188906,0.0001515572,0.0001960413,0.0008538173],"category_scores_gemma":[0.0001203549,0.0001799529,0.0001522928,0.0002052812,0.0000401781,0.0001128652,0.00005302722,0.0001718032,0.00114344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004232423,"about_ca_system_score_gemma":0.0001343862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003545701,"about_ca_topic_score_gemma":0.00002543792,"domain_scores_codex":[0.9987283,0.00007686795,0.0002743198,0.0004068418,0.0000367847,0.0004768874],"domain_scores_gemma":[0.9992605,0.000298625,0.00003665864,0.0002661874,0.00008836031,0.00004964813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001894957,0.0004453548,0.04626077,0.0003878394,0.001929747,0.00006058655,0.0005338497,0.000007037786,0.6326248,0.0009469507,0.2368256,0.07808255],"study_design_scores_gemma":[0.01143574,0.001161963,0.02378065,0.0001166534,0.0003061802,0.000082633,0.0001583324,0.000135707,0.1942471,0.0007575237,0.7673568,0.0004608063],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9078245,0.08573871,0.0003486999,0.002804665,0.0008674486,0.001036106,0.0005272174,0.0003357712,0.0005168558],"genre_scores_gemma":[0.9923669,0.0002458151,0.0002111758,0.0002399637,0.0001080107,0.0002375327,0.0003728521,0.00004359769,0.006174138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5305312,"threshold_uncertainty_score":0.9996343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253234671378306,"score_gpt":0.2973749449744185,"score_spread":0.2748425982606354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}