{"id":"W4394019247","doi":"10.1016/j.vetpar.2024.110181","title":"Genotyping USA laboratory-maintained isolates and European clinical isolates of Dirofilaria immitis to assess macrocyclic lactone susceptibility or resistance at predictive SNP sites using droplet digital PCR","year":2024,"lang":"en","type":"article","venue":"Veterinary Parasitology","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Dirofilaria immitis; Biology; Genotyping; Genotype; Single-nucleotide polymorphism; SNP; Drug resistance; SNP genotyping; Veterinary medicine; Genetics; Immunology; Gene; Medicine; Helminths","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003810572,0.0003227488,0.0007228383,0.0001926274,0.0001496132,0.00008820029,0.0001472736,0.0001370735,0.0002079752],"category_scores_gemma":[0.0006207197,0.0002618794,0.0001498216,0.0003711716,0.0005050215,0.0002337891,0.0003335273,0.0002585165,0.0001044879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206861,"about_ca_system_score_gemma":0.0002293604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003227895,"about_ca_topic_score_gemma":0.00006906887,"domain_scores_codex":[0.9972278,0.0005228647,0.0006554866,0.0008354506,0.0001752149,0.0005831604],"domain_scores_gemma":[0.9977552,0.0009829195,0.0001036413,0.0004663324,0.0001536031,0.0005383339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01201444,0.0006212752,0.8188519,0.0006670328,0.0008991802,0.006285449,0.0003128174,0.000006433564,0.1585129,0.00007606085,0.0003484622,0.001404004],"study_design_scores_gemma":[0.002118569,0.007906641,0.9801273,0.0005974483,0.0003975726,0.001065226,0.0002212525,0.002011097,0.002204247,0.00008235909,0.002861056,0.0004071865],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949068,0.001765748,0.000730594,0.000273611,0.0001902497,0.000637635,0.0008323849,0.0001019989,0.0005609183],"genre_scores_gemma":[0.9975377,0.0001958903,0.001445533,0.0000889013,0.0001492146,0.00002418791,0.0001317033,0.00005175739,0.000375153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1612754,"threshold_uncertainty_score":0.9999834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.107246450667904,"score_gpt":0.4352060451935587,"score_spread":0.3279595945256547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}