{"id":"W4394061609","doi":"10.1101/2024.04.05.588305","title":"Brilacidin, a host defense peptide mimetic, potentiates ibrexafungerp antifungal activity against the human pathogenic fungus <i>Aspergillus fumigatus</i>","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Azrieli Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; International Development Research Centre; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; GlaxoSmithKline","keywords":"Aspergillus fumigatus; Microbiology; Fungus; Antifungal; Aspergillosis; Aspergillus; Peptide; Pathogenic fungus; Biology; Chemistry; Biochemistry; Immunology; Botany","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462443,0.0002172586,0.0001736345,0.000110375,0.00009653419,0.0001879569,0.0001388538,0.0002024697,0.001970404],"category_scores_gemma":[0.0001014896,0.00006986377,0.0001204569,0.00005701819,0.0001100874,0.00008658614,0.0001172935,0.0003213884,0.0005632993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001369362,"about_ca_system_score_gemma":0.00008242623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003143145,"about_ca_topic_score_gemma":0.00028855,"domain_scores_codex":[0.9999204,0.00002212178,0.000006944258,0.00001211279,0.00001734526,0.00002103596],"domain_scores_gemma":[0.9999665,0.000007369812,0.000007657292,0.000003690651,0.000003163746,0.00001153892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004728402,0.00006598734,0.0001497719,0.00003505508,0.000006005149,0.00005573569,0.000007727924,0.0000508305,0.9969972,0.00003266018,0.0002386063,0.001887518],"study_design_scores_gemma":[0.00007150693,0.0008353979,0.003364497,0.000005282312,0.00001532879,0.0004328285,0.0000126352,0.0004261842,0.9912866,0.00001643407,0.003530343,0.000003076101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926878,0.002213464,0.0008963726,0.0002144015,0.00007046893,0.00003065434,0.000440692,0.0001239846,0.00332222],"genre_scores_gemma":[0.9954419,0.0005697904,0.001309169,0.00007460692,0.00002698713,0.00001803237,0.0005408196,0.0000129588,0.002005649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001970404,"threshold_uncertainty_score":0.006591678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01474233050945151,"score_gpt":0.2395435344724768,"score_spread":0.2248012039630252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}