{"id":"W4394063655","doi":"10.1007/s00401-024-02713-1","title":"Metabologenomic characterization uncovers a clinically aggressive IDH mutant glioma subtype","year":2024,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Canadian Cancer Society","keywords":"Isocitrate dehydrogenase; Biology; IDH1; Glioma; CDKN2A; Oligodendroglioma; Cancer research; Mutant; Epigenetics; Phenotype; Transcriptome; IDH2; DNA methylation; Genetics; Astrocytoma; Cancer; Gene; Gene expression; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137303,0.000247823,0.0004062573,0.0001754461,0.00007994219,0.00007786584,0.0001216139,0.0001341078,0.0002599294],"category_scores_gemma":[0.0005350243,0.0001678248,0.000217958,0.0003988249,0.00009526953,0.0001003052,0.00009133131,0.0002412914,0.0004787498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005131689,"about_ca_system_score_gemma":0.00009230535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002682457,"about_ca_topic_score_gemma":4.162735e-7,"domain_scores_codex":[0.9983063,0.000150082,0.0004139209,0.0006150695,0.000206872,0.0003077151],"domain_scores_gemma":[0.9989898,0.0002164196,0.0001839255,0.0003880746,0.0000705083,0.0001512805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002159814,0.0003199831,0.01122121,0.00003200829,0.00007818986,0.03168367,0.0001127365,9.640605e-7,0.9479186,0.0002024246,0.0001932124,0.008021002],"study_design_scores_gemma":[0.003142411,0.004983104,0.7187573,0.000423747,0.001545309,0.01183014,0.00007408889,0.0004046466,0.2037369,0.0003204829,0.05407122,0.0007106487],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945085,0.0005834156,0.0000307819,0.002502628,0.0007949752,0.0004634258,0.00007195622,0.0002994504,0.0007448751],"genre_scores_gemma":[0.996873,0.001132955,0.0001914402,0.001262174,0.0002096632,0.00006484053,0.0001495915,0.00004177885,0.00007457611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7441817,"threshold_uncertainty_score":0.6843697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02237452587314136,"score_gpt":0.2856898853871764,"score_spread":0.263315359514035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}