{"id":"W4394063993","doi":"10.1007/s00204-024-03731-4","title":"Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing","year":2024,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada; U.S. Food and Drug Administration; U.S. Department of Energy","keywords":"DNA damage; Genotoxicity; Comet assay; Micronucleus; Mutagenesis; Molecular biology; Spheroid; Biology; Cytotoxicity; DNA; DNA sequencing; Chemistry; Mutation; Cell culture; Genetics; Micronucleus test; In vitro; Gene; Toxicity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002487525,0.0001101066,0.0001691564,0.00005777687,0.00005216753,0.00001389866,0.0001033842,0.0000803924,0.000008291093],"category_scores_gemma":[0.00006852824,0.00008616602,0.00006693116,0.00009603054,0.0001708756,0.000004970932,0.0001452663,0.0000999196,1.766271e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001945169,"about_ca_system_score_gemma":0.0001426095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002099191,"about_ca_topic_score_gemma":0.0005843635,"domain_scores_codex":[0.9989982,0.0002239868,0.0002713213,0.000263932,0.00008135234,0.0001612226],"domain_scores_gemma":[0.9996218,0.00007264128,0.00008828857,0.0001678795,0.00002389552,0.00002547349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004279025,0.00003163992,0.001433884,0.00006672351,0.0000330322,0.000003136797,0.0006795548,0.006359939,0.9871184,0.00006021076,0.000008829995,0.004161832],"study_design_scores_gemma":[0.0002261997,0.0004944151,0.0031749,0.00002178323,0.00003836423,0.00002345934,0.0003182848,0.1862028,0.8092095,0.0001756436,0.00002826735,0.00008631578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939928,0.002913977,0.002447757,0.0000635875,0.0001160526,0.0002175426,0.00002408375,0.000004261366,0.0002199159],"genre_scores_gemma":[0.9915083,0.0001205309,0.008140666,0.00005976517,0.00008381412,0.0000104042,0.00002918503,0.000008568745,0.00003875696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1798429,"threshold_uncertainty_score":0.3513748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08771214281100688,"score_gpt":0.363527056502267,"score_spread":0.2758149136912601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}