{"id":"W4394146671","doi":"10.6084/m9.figshare.13049345","title":"Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1","year":2020,"lang":"en","type":"dataset","venue":"Figshare","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Oxidative stress; mitochondrial fusion; Mitochondrion; CHOP; Neuroprotection; Reperfusion injury; Serine protease; Cell biology; Pharmacology; Biology; Ischemia; Medicine; Mitochondrial DNA; Protease; Gene; Biochemistry; Internal medicine; Endoplasmic reticulum; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550025,0.000665992,0.0006013314,0.000301754,0.0001530363,0.0002604128,0.0001409794,0.0003080439,0.00100067],"category_scores_gemma":[0.0001077644,0.0001688995,0.0005089362,0.0002474208,0.0002436279,0.0002901431,0.0001709331,0.0007329611,0.0002342242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001907983,"about_ca_system_score_gemma":0.0001808407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004506218,"about_ca_topic_score_gemma":0.0006185967,"domain_scores_codex":[0.9998579,0.00001922447,0.00001852732,0.00002464402,0.00002854577,0.00005121483],"domain_scores_gemma":[0.999898,0.000009146201,0.00004110156,0.00001065925,0.00001141361,0.00002968794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003888632,0.00005011411,0.0002373683,0.00005907662,0.00001612438,0.00009308969,0.00001612713,0.00002578266,0.9981907,0.00003209913,0.0000317192,0.0008588666],"study_design_scores_gemma":[0.00002551085,0.0006949986,0.004497902,0.000005694158,0.00004375852,0.0003999084,0.00003172707,0.0003968867,0.9932869,0.00003074779,0.0005820786,0.000003893113],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9906058,0.005248121,0.002931976,0.0001369378,0.00004086147,0.00002442287,0.000216435,0.00008917121,0.000706457],"genre_scores_gemma":[0.9920973,0.003013955,0.00239321,0.00008368384,0.00003343224,0.0000485941,0.0005615485,0.00001635675,0.001751948],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.00100067,"threshold_uncertainty_score":0.003347576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009843108694032442,"score_gpt":0.2505349033229894,"score_spread":0.240691794628957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}