{"id":"W4394146955","doi":"10.6084/m9.figshare.19391051","title":"Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against hypoxia-reperfusion injury <i>in vitro</i> by activating liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling","year":2022,"lang":"en","type":"dataset","venue":"Figshare","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"AMPK; Protein kinase A; Cell biology; Hypoxia (environmental); AMP-activated protein kinase; Chemistry; Hepatocyte; In vitro; Gene silencing; Kinase; Biology; Biochemistry; Gene; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003118674,0.0004356804,0.0007056752,0.0003850947,0.0003957388,0.0004444496,0.0002963092,0.0004233085,0.003692832],"category_scores_gemma":[0.000204351,0.000280254,0.0007832365,0.0003096649,0.0004318445,0.0004594778,0.000285671,0.0009334757,0.0008692221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000402377,"about_ca_system_score_gemma":0.0004884716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001317624,"about_ca_topic_score_gemma":0.002056716,"domain_scores_codex":[0.9995839,0.00004176134,0.00005764087,0.000113483,0.00009977959,0.0001034372],"domain_scores_gemma":[0.9998671,0.00001200932,0.00004027303,0.00001547159,0.00002765584,0.0000374786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007406656,0.00006908076,0.0007707556,0.0004315533,0.00003529417,0.0001076992,0.00007102622,0.0001441425,0.9928164,0.0002400615,0.000664602,0.003908662],"study_design_scores_gemma":[0.0001326191,0.0009284671,0.009548934,0.00004983561,0.0001595534,0.0004649622,0.0002289727,0.002173193,0.9714251,0.0002081977,0.01465461,0.0000256091],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9592349,0.01712236,0.01211804,0.000892432,0.0006521546,0.0001164566,0.00298376,0.0008830763,0.005996838],"genre_scores_gemma":[0.9767766,0.006072924,0.004283912,0.0004550577,0.00006144562,0.0001958112,0.002640057,0.00009697049,0.009417266],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.003692832,"threshold_uncertainty_score":0.01235378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03134268782477372,"score_gpt":0.2433586475052461,"score_spread":0.2120159596804723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}