{"id":"W4394239353","doi":"10.6084/m9.figshare.22104764","title":"Pharmacokinetics, pharmacodynamics, safety and immunogenicity of Gerilimzumab (GB224), a recombinant humanized interleukin-6 monoclonal antibody, in healthy Chinese adults: A randomized controlled dose-escalation study","year":2023,"lang":"en","type":"dataset","venue":"Figshare","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Immunogenicity; Pharmacokinetics; Pharmacodynamics; Monoclonal antibody; Medicine; Recombinant DNA; Pharmacology; Humanized antibody; Immunology; Antibody; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001966902,0.0009508219,0.002353929,0.0005692383,0.0003623492,0.001051792,0.00200138,0.001353306,0.02225489],"category_scores_gemma":[0.0051922,0.0003892376,0.002005507,0.001894812,0.000242779,0.0005543092,0.0006163386,0.001270635,0.006901387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001444105,"about_ca_system_score_gemma":0.002054577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007009787,"about_ca_topic_score_gemma":0.009297758,"domain_scores_codex":[0.9992616,0.0002169931,0.0001311974,0.0001546699,0.0001599879,0.00007560746],"domain_scores_gemma":[0.997433,0.0009008048,0.0005797481,0.000479246,0.0003896878,0.0002175168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1048232,0.001719827,0.03733287,0.01622467,0.00857602,0.0001535894,0.00007557128,0.003042277,0.001422001,0.0008936932,0.7567969,0.06893939],"study_design_scores_gemma":[0.2525715,0.006267984,0.3047992,0.004105117,0.02033515,0.0009035207,0.0001478103,0.00976034,0.003080806,0.004832577,0.3927711,0.0004248045],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.02043028,0.00288272,0.0003819629,0.0005037744,0.00005805083,0.0004610423,0.9726787,0.0001714416,0.002431981],"genre_scores_gemma":[0.08531111,0.002712678,0.001464769,0.001068069,0.00008656946,0.004132605,0.9002231,0.0001165268,0.004884658],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.02225489,"threshold_uncertainty_score":0.07445002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02105094005834642,"score_gpt":0.3697166377938583,"score_spread":0.3486656977355119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}