{"id":"W4394566083","doi":"10.1016/j.isci.2024.109684","title":"Time of day and circadian disruption influence host response and parasite growth in a mouse model of cerebral malaria","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Malaria Research and Control","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Faculty of Medicine and Health, University of Sydney; McGill University","keywords":"Circadian rhythm; Parasite hosting; Malaria; Cerebral Malaria; Biology; Host (biology); Host response; Immune system; Immunology; Plasmodium falciparum; Neuroscience; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000834331,0.00005884736,0.0001399672,0.0002052519,0.00002004741,0.00002305532,0.00006927582,0.00003813487,0.00001190718],"category_scores_gemma":[0.0004768005,0.00004753103,0.00001600747,0.0002674236,0.0003458017,0.0002242831,0.00004649768,0.0001087085,0.000003612184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001876951,"about_ca_system_score_gemma":0.0001799011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001262349,"about_ca_topic_score_gemma":0.00001764284,"domain_scores_codex":[0.9991958,0.00006237299,0.0001465767,0.000203986,0.000224273,0.0001670063],"domain_scores_gemma":[0.9995722,0.0001199708,0.00002271181,0.0001180431,0.00004802792,0.0001191159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006118314,0.00003045886,0.02765929,0.0001380959,0.000005541652,0.00002232752,0.001793988,0.00005627144,0.9654227,0.003508703,0.000008114805,0.0007426635],"study_design_scores_gemma":[0.0006694503,0.0002722058,0.6960571,0.0001839044,0.00001068963,0.00001803653,0.0000624789,0.2882268,0.01405935,0.0003718144,0.000004875668,0.00006325354],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968596,0.0003895185,0.0003188289,0.002069063,0.000006752695,0.0001987811,0.00002760706,0.000009660841,0.0001201983],"genre_scores_gemma":[0.999055,0.00004412878,0.0002067777,0.00005075019,0.000005499005,0.000007552706,7.403533e-7,0.000004161713,0.0006254108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9513634,"threshold_uncertainty_score":0.1938259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01237709762930076,"score_gpt":0.2820151444233437,"score_spread":0.269638046794043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}