{"id":"W4394568323","doi":"10.1038/s41467-024-47280-x","title":"Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"H2020 European Research Council; Fondation Mérieux; Institut National Du Cancer; Fondation ARC pour la Recherche sur le Cancer; Société Française de lutte contre les Cancers et les leucémies de l'Enfant et de l'Adolescent; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Ligue Contre le Cancer","keywords":"Biology; Epigenetics; Chromatin; Cellular differentiation; Progenitor cell; Somatic evolution in cancer; Phenotype; Transcription factor; Transcriptome; Stem cell; Somatic cell; Genetics; Phenotypic plasticity; Cell; Population; Cell fate determination; Cell biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468992,0.00009396099,0.00009445882,0.00005780648,0.00007462308,0.00002350605,0.0003840064,0.0002381322,0.000001985907],"category_scores_gemma":[0.00008263913,0.00007638653,0.00005457788,0.0001467564,0.0001861907,0.000005313764,0.0001647049,0.000437307,0.000001381009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002743916,"about_ca_system_score_gemma":0.0000456927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003514297,"about_ca_topic_score_gemma":0.0007431209,"domain_scores_codex":[0.9993602,0.0001006094,0.0002039547,0.0001616724,0.00007021737,0.0001033393],"domain_scores_gemma":[0.999281,0.0001314995,0.00004271587,0.0004590398,0.00005931374,0.00002638036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000314742,0.0001321036,0.00611895,0.00003386718,0.00001803831,5.165158e-7,0.0001725023,0.00002455452,0.9908671,0.001770153,0.0004049539,0.0004257386],"study_design_scores_gemma":[0.001188276,0.0004698422,0.01503254,0.0003575533,0.0001252847,0.00003578981,0.0004232574,0.03371437,0.8739691,0.001148499,0.07298993,0.0005454987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981795,0.01446693,0.002423498,0.0004684753,0.00015211,0.0001479998,0.00006481218,0.00001225647,0.0004689672],"genre_scores_gemma":[0.997865,0.0004273742,0.001405979,0.00007858797,0.00004426416,0.0000107119,0.00008799131,0.0000132297,0.00006685116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.116898,"threshold_uncertainty_score":0.3114952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01213170141668227,"score_gpt":0.2576373394270858,"score_spread":0.2455056380104035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}