{"id":"W4394569335","doi":"10.1016/j.jacc.2024.03.380","title":"Randomized Trial of a Selective Aldose Reductase Inhibitor in Patients With Diabetic Cardiomyopathy","year":2024,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Medical Research Council; National Institutes of Health; Alexion Pharmaceuticals; Amarin Corporation; Alnylam Pharmaceuticals; European Association for the Study of Diabetes; Novo Nordisk; National Medical Research Council; Cytokinetics; American Regent; Sanofi; Amgen; Pfizer; European Foundation for the Study of Diabetes; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Placebo; Dulaglutide; Internal medicine; Heart failure; Aldose reductase inhibitor; Cardiology; Diabetes mellitus; Endocrinology; Type 2 diabetes; Gastroenterology; Aldose reductase; Exenatide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00181813,0.002147625,0.005902784,0.0004581941,0.0006842186,0.002031378,0.001155784,0.002559696,0.01040684],"category_scores_gemma":[0.002106452,0.001178894,0.003356963,0.0005253276,0.001856007,0.001608731,0.0007726218,0.004679299,0.001338575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001299088,"about_ca_system_score_gemma":0.001396434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002116765,"about_ca_topic_score_gemma":0.004049012,"domain_scores_codex":[0.9989512,0.000499165,0.00007847769,0.0002156814,0.00005049048,0.0002049992],"domain_scores_gemma":[0.9987473,0.0004057794,0.0002007181,0.0001064191,0.00008141452,0.0004582837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.994832,0.0007720983,0.0003283388,0.0001750945,0.0007687585,0.00001952462,0.00001100207,0.0001112132,0.000492115,0.00008271076,0.0002729659,0.002134068],"study_design_scores_gemma":[0.9881293,0.009759142,0.0007534663,0.00001831153,0.0006718143,0.00001210378,0.00001301559,0.000165721,0.00007808169,0.0001055272,0.0002854936,0.000007995366],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729162,0.009232113,0.00153969,0.003152237,0.003794992,0.002258492,0.001753094,0.0002208314,0.005132242],"genre_scores_gemma":[0.9853284,0.002771873,0.00125566,0.002870051,0.001388813,0.001602872,0.001398174,0.00002799404,0.003356177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01040684,"threshold_uncertainty_score":0.0348143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003758062721697707,"score_gpt":0.2261171690385138,"score_spread":0.2223591063168161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}