{"id":"W4394569335","doi":"10.1016/j.jacc.2024.03.380","title":"Randomized Trial of a Selective Aldose Reductase Inhibitor in Patients With Diabetic Cardiomyopathy","year":2024,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Medical Research Council; National Institutes of Health; Alexion Pharmaceuticals; Amarin Corporation; Alnylam Pharmaceuticals; European Association for the Study of Diabetes; Novo Nordisk; National Medical Research Council; Cytokinetics; American Regent; Sanofi; Amgen; Pfizer; European Foundation for the Study of Diabetes; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Placebo; Dulaglutide; Internal medicine; Heart failure; Aldose reductase inhibitor; Cardiology; Diabetes mellitus; Endocrinology; Type 2 diabetes; Gastroenterology; Aldose reductase; Exenatide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006787081,0.0001490055,0.001158742,0.0001671685,0.00001786869,0.000003006299,0.000209417,0.0000605662,0.000001072568],"category_scores_gemma":[0.0003097957,0.00008756868,0.0005346707,0.0004225219,0.0006426676,0.000006163722,0.00007992214,0.0001863413,2.298079e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003525237,"about_ca_system_score_gemma":0.000463175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000104317,"about_ca_topic_score_gemma":0.00000175039,"domain_scores_codex":[0.9981666,0.000675204,0.0005940843,0.0001708446,0.0002227022,0.0001706045],"domain_scores_gemma":[0.9987537,0.0001101877,0.0005763742,0.0002522585,0.0002595293,0.00004800917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9535102,0.0001977193,0.006553119,0.00005983877,0.002624093,0.0001030805,0.00006751867,0.0006283833,0.03193722,0.00007034228,0.003387257,0.000861185],"study_design_scores_gemma":[0.8694139,0.01290729,0.006975631,0.0003056235,0.001191289,0.0004760288,0.0003528965,0.00002074302,0.1033974,0.0004285413,0.00412624,0.0004044665],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975296,0.000979173,0.00005439609,0.0001897833,0.0004611184,0.0004918203,0.0001016486,0.000001637649,0.0001907961],"genre_scores_gemma":[0.999088,0.0001897763,0.0001580328,0.00002464033,0.0004736696,0.00001287891,0.000005297828,0.0000179394,0.00002968828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08409639,"threshold_uncertainty_score":0.3570947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003758062721697707,"score_gpt":0.2261171690385138,"score_spread":0.2223591063168161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}