{"id":"W4394574380","doi":"10.1101/2024.04.07.588476","title":"The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Genomics; Genome Canada","keywords":"Sister chromatids; Sister chromatid exchange; Genetics; Biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156809,0.0003100401,0.0002279835,0.0003149342,0.0002181333,0.0003628409,0.00027983,0.000272034,0.003422992],"category_scores_gemma":[0.00008100301,0.0001662931,0.0002178068,0.0001364431,0.0002170583,0.0001216009,0.0003028868,0.0004530207,0.001097825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004362331,"about_ca_system_score_gemma":0.0001409725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006558101,"about_ca_topic_score_gemma":0.0009569114,"domain_scores_codex":[0.999833,0.00001664609,0.000009443734,0.000041381,0.00007160285,0.00002787344],"domain_scores_gemma":[0.9999069,0.0000159469,0.00002899847,0.00001171645,0.000006785567,0.00002962172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005782282,0.000009694629,0.0001138346,0.00001246035,0.000002785675,0.00003702676,0.000003880036,0.00003111668,0.99925,0.00006670177,0.00007073272,0.0003440534],"study_design_scores_gemma":[0.00001349797,0.00005251301,0.005058623,0.00000380481,0.000006511693,0.000246483,0.00001505709,0.001099296,0.990635,0.00004645846,0.002820136,0.000002707587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865654,0.001732684,0.004884561,0.000310352,0.00005257487,0.00001900783,0.001239855,0.0003326035,0.004862968],"genre_scores_gemma":[0.9885718,0.0002983079,0.002547016,0.00010312,0.00001033028,0.00001725643,0.001586449,0.0001035595,0.006762104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003422992,"threshold_uncertainty_score":0.01145107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164760590734032,"score_gpt":0.2164154779286538,"score_spread":0.2047678720213135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}