{"id":"W4394579849","doi":"10.1001/jamapediatrics.2024.0492","title":"Clinical Effectiveness of Newborn Screening for Spinal Muscular Atrophy","year":2024,"lang":"en","type":"letter","venue":"JAMA Pediatrics","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Medicine; Newborn screening; Spinal muscular atrophy; Pediatrics; Cohort; SMA*; Clinical trial; Cohort study; Disease; Physical therapy; Neuromuscular disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001549441,0.0003879194,0.001099983,0.0005228671,0.00005579635,0.00005363919,0.0003195477,0.001368426,0.00002754744],"category_scores_gemma":[0.001219538,0.0003394295,0.001521999,0.0005791987,0.0001718853,0.00003581687,0.0002032083,0.002849607,0.00004763548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004878953,"about_ca_system_score_gemma":0.0006141212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002417887,"about_ca_topic_score_gemma":4.429737e-7,"domain_scores_codex":[0.9963679,0.0003978812,0.00075925,0.000845683,0.001033867,0.0005953946],"domain_scores_gemma":[0.9972751,0.00113984,0.0001969349,0.000711232,0.0005030142,0.0001738347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001291119,0.0001577845,0.008490986,0.03008426,0.0005729134,0.00146097,0.00001212516,0.00000656298,0.00007588347,0.00002562122,0.8557426,0.1020792],"study_design_scores_gemma":[0.003169668,0.002150503,0.009890444,0.0005346483,0.002093765,0.00005351086,0.00000893356,0.0001355848,0.00005716212,0.0002358485,0.9813623,0.0003075631],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1125506,0.08177116,0.2305589,0.5434421,0.008341267,0.01808268,0.001255268,0.000567219,0.003430742],"genre_scores_gemma":[0.02161145,0.02327461,0.133322,0.6158268,0.1855527,0.002077086,0.006547718,0.002476307,0.009311289],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1772114,"threshold_uncertainty_score":0.999928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05653503125254493,"score_gpt":0.3867351687094878,"score_spread":0.3302001374569429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}