{"id":"W4394581520","doi":"10.1073/pnas.2317290121","title":"Pregnancy is linked to faster epigenetic aging in young women","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pacific Centre for Reproductive Medicine; BC Children's Hospital; Canadian Institute for Advanced Research; University of British Columbia","funders":"National Institute on Aging; Division of Behavioral and Cognitive Sciences; Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Epigenetics; Fertility; Pregnancy; Context (archaeology); Biological age; Demography; Longitudinal study; Gerontology; Biology; Cohort; Healthy aging; Ageing; Physiology; Medicine; Genetics; Population; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003075474,0.0001034206,0.0001068621,0.0003398664,0.0002371242,0.0002401446,0.0001343565,0.0001608567,0.0009672297],"category_scores_gemma":[0.001548175,0.0001391565,0.0001840885,0.0003560917,0.0001818545,0.0001659633,0.0002669992,0.0002262557,0.00006969163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001506101,"about_ca_system_score_gemma":0.0002254458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005592879,"about_ca_topic_score_gemma":0.008188146,"domain_scores_codex":[0.9998857,0.00003195796,0.00000929916,0.00003999162,0.00001418415,0.00001887387],"domain_scores_gemma":[0.9993066,0.0001168158,0.000420081,0.00004623653,0.00004230651,0.00006802963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005907505,0.000006412307,0.9962716,0.000008637536,0.00002613594,0.00006514134,0.0001100079,0.00002595719,0.0004342897,0.00003424624,0.00004368047,0.002914864],"study_design_scores_gemma":[8.181928e-7,0.00002939708,0.9994383,0.000004233048,0.00001158874,0.0001187309,0.00006125148,0.00009058582,0.00008949776,0.00003930115,0.0001149411,0.000001338021],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985605,0.0006993645,0.0001716256,0.00008779297,0.000008941118,0.000003385649,0.0001248114,0.000004550634,0.0003391537],"genre_scores_gemma":[0.999356,0.0003046394,0.0001133652,0.00002163242,0.000007598352,0.000002585877,0.00005683833,8.908201e-7,0.0001363919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005592879,"threshold_uncertainty_score":0.01112068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02768156967689043,"score_gpt":0.3148775490116377,"score_spread":0.2871959793347473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}