{"id":"W4394598661","doi":"10.1212/wnl.0000000000205867","title":"The Impact of Disease Severity on Responder Rates in a Phase 2b Study of XEN1101, a Potent, Selective Potassium Channel Opener, in Adults with Focal Epilepsy (X-TOLE) (S19.004)","year":2024,"lang":"en","type":"article","venue":"Neurology","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Epilepsy; Potassium channel opener; Medicine; Potassium; Anesthesia; Potassium channel; Pharmacology; Internal medicine; Chemistry; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00445759,0.0008154872,0.001158128,0.0003036191,0.0001767696,0.0005405371,0.0003349824,0.0009155881,0.002336543],"category_scores_gemma":[0.004236058,0.0003037358,0.001503345,0.0002152295,0.0003732939,0.000811714,0.0003466443,0.001788398,0.0003169813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003184328,"about_ca_system_score_gemma":0.0004315626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004115463,"about_ca_topic_score_gemma":0.001051734,"domain_scores_codex":[0.9977825,0.0015899,0.0001829722,0.0001454001,0.0001503447,0.0001489658],"domain_scores_gemma":[0.9972175,0.001308035,0.000696163,0.0001617002,0.0001422529,0.0004742631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8532838,0.01195471,0.01422894,0.0005392805,0.002635618,0.0001114943,0.0001290955,0.001560461,0.024234,0.0001318521,0.001611307,0.08957945],"study_design_scores_gemma":[0.3050645,0.5738336,0.1073393,0.0000657354,0.00218318,0.0003175785,0.00007152297,0.002346673,0.006298811,0.0002051969,0.002198098,0.00007563515],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993422,0.003107925,0.0004882216,0.0004370693,0.000101887,0.0005312377,0.0005644461,0.00004765449,0.001299642],"genre_scores_gemma":[0.9956595,0.0008895898,0.0009097084,0.0005365924,0.0002010071,0.0003675134,0.0006037375,0.0000184928,0.0008137538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00445759,"threshold_uncertainty_score":0.02357429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0186580927916085,"score_gpt":0.3522535315444176,"score_spread":0.3335954387528091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}