{"id":"W4394599810","doi":"10.1212/wnl.0000000000205151","title":"Safety Profile of IPX203 in Patients Exposed for 12 Months in a Phase 3 Study in PD by Modal Dose Distribution (P9-3.004)","year":2024,"lang":"en","type":"article","venue":"Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"","keywords":"Adverse effect; Medicine; Modal; Maximum tolerated dose; Distribution (mathematics); Phase (matter); Internal medicine; Materials science; Mathematics; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009869486,0.0004277386,0.0008037018,0.0002184688,0.0002663392,0.0004559289,0.0002989259,0.0006208334,0.003350398],"category_scores_gemma":[0.0007254242,0.0001962852,0.0007533127,0.0002300606,0.0002707596,0.0004397838,0.0001533831,0.001851309,0.0005035885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003054016,"about_ca_system_score_gemma":0.0005479335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004276922,"about_ca_topic_score_gemma":0.0009751001,"domain_scores_codex":[0.9997758,0.0001040271,0.00001213703,0.00003192946,0.0000319053,0.00004413259],"domain_scores_gemma":[0.9995682,0.0001024725,0.0001093935,0.00003476939,0.00003855641,0.0001465855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.538929,0.03782697,0.02344088,0.0008615781,0.001864842,0.0006548702,0.0005308072,0.003938274,0.1507543,0.0003545454,0.003641051,0.2372029],"study_design_scores_gemma":[0.1343812,0.7552833,0.08764572,0.00008907638,0.0008470212,0.0007884564,0.0001328555,0.002707611,0.01336755,0.0003719278,0.004324237,0.00006112352],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966184,0.000926311,0.000450824,0.0001462346,0.0000288927,0.0004080663,0.0004608195,0.00005517839,0.0009053614],"genre_scores_gemma":[0.9965861,0.0004696375,0.0007040718,0.0002861445,0.00003689235,0.0003705744,0.0004546698,0.00001398632,0.001077763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003350398,"threshold_uncertainty_score":0.01120824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01555992323920803,"score_gpt":0.2913047197132167,"score_spread":0.2757447964740087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}