{"id":"W4394600257","doi":"10.1212/wnl.0000000000204857","title":"Dysregulation of Adipocyte Response in Amyotrophic Lateral Sclerosis: Developing the Humanized in Vitro Model System to Screen for Immuno-metabolic Molecular Signatures (P5-11.001)","year":2024,"lang":"en","type":"article","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval","funders":"","keywords":"Amyotrophic lateral sclerosis; Adipocyte; In vitro; Medicine; Neuroscience; Biology; Immunology; Internal medicine; Disease; Biochemistry; Adipose tissue","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008694904,0.0005635687,0.0004354277,0.0005644885,0.0003626889,0.0007132996,0.0005117952,0.0005397993,0.003086483],"category_scores_gemma":[0.0003424455,0.0002746963,0.0005427568,0.0002327871,0.0003842701,0.0004099776,0.0004700553,0.001284625,0.001458453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004594975,"about_ca_system_score_gemma":0.0004463753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001514812,"about_ca_topic_score_gemma":0.00273596,"domain_scores_codex":[0.9995444,0.0001577934,0.0000444706,0.000102961,0.00009369981,0.00005670972],"domain_scores_gemma":[0.9997467,0.00006351807,0.00004074914,0.0000663567,0.00004056295,0.0000420847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005121935,0.0002049909,0.0006394535,0.00006878347,0.00002068607,0.0002019009,0.00005888829,0.0001973415,0.9950655,0.0003010448,0.000454137,0.002275066],"study_design_scores_gemma":[0.0000920563,0.001688031,0.007554144,0.00003121919,0.00008589237,0.001425114,0.0001430787,0.002274029,0.9729578,0.0002998001,0.01342424,0.00002448196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9250576,0.006349196,0.05117203,0.001258655,0.0006917621,0.0004430112,0.007035627,0.0006713466,0.007320634],"genre_scores_gemma":[0.9333463,0.004221224,0.03563596,0.0005120481,0.000092547,0.0007823939,0.007839986,0.000178799,0.01739077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003086483,"threshold_uncertainty_score":0.01032531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0299129723947275,"score_gpt":0.2954768632416424,"score_spread":0.2655638908469148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}