{"id":"W4394600716","doi":"10.1212/wnl.0000000000204709","title":"Impact of Genetic Susceptibility on Multiple Sclerosis Immune Methylome (S17.006)","year":2024,"lang":"en","type":"article","venue":"Neurology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Multiple sclerosis; DNA methylation; Immune system; Methylation; Gene; Genetics; Biology; Colocalization; Immunology; Neuroscience; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002067045,0.0003199412,0.0002723628,0.0003672148,0.0002672047,0.000282393,0.0001814806,0.000484823,0.01374664],"category_scores_gemma":[0.0004301333,0.0001160397,0.0003499039,0.0004159441,0.0001621894,0.0001183353,0.0002391808,0.0004638826,0.001369767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001917936,"about_ca_system_score_gemma":0.0002586976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003545464,"about_ca_topic_score_gemma":0.00486412,"domain_scores_codex":[0.9998477,0.00003399909,0.00001208957,0.0000401516,0.00002781771,0.00003842306],"domain_scores_gemma":[0.9997309,0.00006379814,0.00007871455,0.00002885266,0.00002999412,0.00006776564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007341337,0.0005561155,0.127125,0.0002275302,0.0006688422,0.001215578,0.0002356341,0.001143817,0.8279198,0.001747903,0.002752386,0.02906589],"study_design_scores_gemma":[0.0006923596,0.003095671,0.6844501,0.0001365682,0.0009408572,0.004957192,0.0004267345,0.005009794,0.2628337,0.002809258,0.03458824,0.00005941662],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940831,0.0003914938,0.0006350667,0.0002640132,0.00006658318,0.00001579478,0.00262905,0.0000477792,0.001867142],"genre_scores_gemma":[0.9945307,0.0001551958,0.000733487,0.0001946609,0.00001466387,0.00002419246,0.001227437,0.00006157626,0.003058043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01374664,"threshold_uncertainty_score":0.04598713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02388417194959055,"score_gpt":0.2831697474716949,"score_spread":0.2592855755221044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}