{"id":"W4394601038","doi":"10.1212/wnl.0000000000205177","title":"Long-term Efficacy of the Sphingosine 1-Phosphate Receptor Modulator Ozanimod by Age Category in Patients with Relapsing Multiple Sclerosis: Final Results from Two Phase 3 Trials and an Open-label Extension Trial (P2-6.007)","year":2024,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; NeuroRx Research (Canada)","funders":"","keywords":"Open label; Medicine; Term (time); Sphingosine; Sphingosine-1-phosphate receptor; Internal medicine; Clinical trial; Receptor; Pediatrics; Sphingosine-1-phosphate","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003111303,0.00114492,0.002476405,0.0003530903,0.000398051,0.0007301582,0.0007233636,0.001325184,0.002921173],"category_scores_gemma":[0.001552331,0.0003500214,0.002270693,0.0004247607,0.0006235336,0.001061762,0.0005436598,0.002283635,0.0005322798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005343016,"about_ca_system_score_gemma":0.0008964271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046577,"about_ca_topic_score_gemma":0.003427519,"domain_scores_codex":[0.9991608,0.0004590715,0.00006401083,0.00008770964,0.00007302392,0.0001555232],"domain_scores_gemma":[0.9985859,0.0003553384,0.0003265007,0.0001020034,0.0001419406,0.000488278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9558465,0.00365641,0.002741838,0.0005469653,0.001897551,0.00004303975,0.00008097615,0.0002389095,0.006051866,0.00006478222,0.0008253418,0.02800581],"study_design_scores_gemma":[0.813446,0.1544015,0.02719316,0.00008005054,0.001924918,0.00008971847,0.00006883639,0.000257015,0.00107599,0.0001888937,0.001236974,0.00003683767],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851221,0.01124734,0.0002407743,0.0004848124,0.0001496906,0.0006215341,0.001034041,0.00003696914,0.001062738],"genre_scores_gemma":[0.9879946,0.00493794,0.001158862,0.0009574997,0.0002914158,0.001043841,0.002197834,0.00001557758,0.001402656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003111303,"threshold_uncertainty_score":0.01645434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1492133734818138,"score_gpt":0.3772370436683688,"score_spread":0.228023670186555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}