{"id":"W4394618759","doi":"10.1186/s40170-024-00341-7","title":"Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma","year":2024,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; Medical School, University of Michigan; National Cancer Institute; National Institutes of Health; Leah's Happy Hearts; Pediatric Brain Tumor Foundation; Ian's Friends Foundation; Alex's Lemonade Stand Foundation for Childhood Cancer; Sontag Foundation; Rogel Cancer Center, University of Michigan; Damon Runyon Cancer Research Foundation","keywords":"Hypoxanthine-guanine phosphoribosyltransferase; Hypoxanthine; Purine; Purine metabolism; Biochemistry; Biology; Chemistry; Molecular biology; Mutant; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357419,0.0002735406,0.0003211067,0.0003342588,0.00009846932,0.00031255,0.0001885328,0.0002336434,0.001108014],"category_scores_gemma":[0.0001951697,0.0001138867,0.0002616574,0.0003311473,0.0001559089,0.0001448512,0.0002048879,0.000378324,0.0002494843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004454014,"about_ca_system_score_gemma":0.0002096515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001958217,"about_ca_topic_score_gemma":0.002598481,"domain_scores_codex":[0.9998913,0.00001087707,0.000006817166,0.00003442059,0.00003887419,0.00001776981],"domain_scores_gemma":[0.9998726,0.00001933592,0.00004831365,0.00001686519,0.0000164755,0.00002643694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006275962,0.00006393012,0.005336961,0.00008997641,0.00004787981,0.0001308922,0.00002498757,0.0004928486,0.986517,0.00003932814,0.0001947249,0.006433876],"study_design_scores_gemma":[0.00004279959,0.001436605,0.0703283,0.00001758593,0.0001081717,0.001123173,0.0001014829,0.003797783,0.9194472,0.0001609169,0.0034191,0.00001687905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969484,0.0008334769,0.0009265664,0.00004268576,0.000005390875,0.00001528595,0.0008862979,0.00009247571,0.0002495031],"genre_scores_gemma":[0.9957973,0.0005278485,0.0009435514,0.00003663745,0.000002663466,0.00002013818,0.002146435,0.00002661035,0.0004989738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001958217,"threshold_uncertainty_score":0.003893614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01984490041380862,"score_gpt":0.3047120837147619,"score_spread":0.2848671833009533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}