{"id":"W4394618759","doi":"10.1186/s40170-024-00341-7","title":"Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma","year":2024,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; Medical School, University of Michigan; National Cancer Institute; National Institutes of Health; Leah's Happy Hearts; Pediatric Brain Tumor Foundation; Ian's Friends Foundation; Alex's Lemonade Stand Foundation for Childhood Cancer; Sontag Foundation; Rogel Cancer Center, University of Michigan; Damon Runyon Cancer Research Foundation","keywords":"Hypoxanthine-guanine phosphoribosyltransferase; Hypoxanthine; Purine; Purine metabolism; Biochemistry; Biology; Chemistry; Molecular biology; Mutant; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001079109,0.0003947653,0.0007166861,0.0003656793,0.00005600786,0.00007433563,0.0001002138,0.0001031207,0.001257419],"category_scores_gemma":[0.0000522461,0.0002746362,0.0002333275,0.0007772954,0.00007382229,0.0001201099,0.00003856461,0.0001619785,0.0001106586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004985037,"about_ca_system_score_gemma":0.0002437169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004658967,"about_ca_topic_score_gemma":0.001273236,"domain_scores_codex":[0.9979993,0.00004927556,0.0004406792,0.0006859713,0.0003261083,0.0004987331],"domain_scores_gemma":[0.9990099,0.0001049132,0.00005962332,0.0005237459,0.00006471328,0.0002370825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002733211,0.01848218,0.03036438,0.002848167,0.005034267,0.06051868,0.01044302,0.0000339442,0.5104246,0.02260404,0.04281655,0.293697],"study_design_scores_gemma":[0.008243921,0.0002417402,0.08686918,0.001306222,0.00099073,0.0001003326,0.00005898094,0.0001716319,0.1725061,0.0008476095,0.7282069,0.0004566779],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8322609,0.1590302,0.00000385764,0.00561068,0.0006483091,0.0008634187,0.000542472,0.0001757763,0.0008643725],"genre_scores_gemma":[0.9883391,0.005730894,0.0005923182,0.0002191344,0.0007537459,0.00151686,0.000126727,0.00007985478,0.00264131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6853903,"threshold_uncertainty_score":0.9999706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01984490041380862,"score_gpt":0.3047120837147619,"score_spread":0.2848671833009533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}