{"id":"W4394619694","doi":"10.1007/s00210-024-03052-4","title":"A new approach of nano-metformin as a protector against radiation-induced cardiac fibrosis and inflammation via CXCL1/TGF-Β pathway","year":2024,"lang":"en","type":"article","venue":"Naunyn-Schmiedeberg s Archives of Pharmacology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Science and Technology Development Fund","keywords":"CXCL1; Fibrosis; Inflammation; Medicine; Cardiac fibrosis; Growth factor; Transforming growth factor; Metformin; Internal medicine; Myocardial fibrosis; Endocrinology; Pharmacology; Cancer research; Insulin; Receptor; Chemokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007678237,0.0002154402,0.000175395,0.0002396014,0.000147279,0.0001563267,0.0001668732,0.0002756436,0.0009281036],"category_scores_gemma":[0.00004871425,0.00008148016,0.0002336163,0.00007708184,0.0001311523,0.00024726,0.0001440509,0.0003640061,0.000102109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001375672,"about_ca_system_score_gemma":0.0001732492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002306237,"about_ca_topic_score_gemma":0.0007154857,"domain_scores_codex":[0.9999672,0.000005117861,0.000002006352,0.000009456303,0.00000985744,0.0000063312],"domain_scores_gemma":[0.9999802,0.000002665334,0.000005927474,0.000001833229,0.000003913538,0.000005362473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002109991,0.0001253217,0.000283839,0.000296598,0.00001510785,0.000115628,0.00002303028,0.0001655368,0.9820946,0.0004724004,0.0001427982,0.01605423],"study_design_scores_gemma":[0.00008950143,0.00206202,0.002665274,0.0000305836,0.00006830497,0.0006415101,0.00004517542,0.001522066,0.9761644,0.0002468731,0.01644967,0.00001466276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517047,0.01879302,0.02257725,0.000807598,0.0003059544,0.0001787454,0.000234031,0.0001264233,0.005272346],"genre_scores_gemma":[0.9705969,0.008342868,0.01536102,0.0002710451,0.00006324521,0.0001144812,0.0001559609,0.00001497905,0.005079454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009281036,"threshold_uncertainty_score":0.003104806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079609344447882,"score_gpt":0.274784556917061,"score_spread":0.2639884634725822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}