{"id":"W4394621465","doi":"10.1093/ibd/izae076","title":"Tofacitinib as a Rescue Therapy for Ulcerative Colitis in Pregnancy","year":2024,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Pregnancy and Medication Impact","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Rockyview General Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Genentech; Alberta Children's Hospital Research Institute; Celltrion; Leona M. and Harry B. Helmsley Charitable Trust; Mylan; Celgene; Biogen; Gilead Sciences; New South Wales Government; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Tofacitinib; Ulcerative colitis; Medicine; Ustekinumab; Pregnancy; Rescue therapy; Colectomy; Maintenance therapy; Janus kinase inhibitor; Inflammatory bowel disease; Salvage therapy; Gastroenterology; Internal medicine; Surgery; Adalimumab; Chemotherapy; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002296499,0.0001768655,0.0004150093,0.0002668834,0.0002520166,0.0002120837,0.0001585978,0.0003863036,0.0007213503],"category_scores_gemma":[0.0005278295,0.00004658657,0.0002774421,0.0001735858,0.0001743798,0.00009429684,0.0001371394,0.001090255,0.0002100861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003611794,"about_ca_system_score_gemma":0.0003509764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006836554,"about_ca_topic_score_gemma":0.001071229,"domain_scores_codex":[0.9999233,0.00002144712,0.000008784378,0.00001042917,0.00001525098,0.00002066952],"domain_scores_gemma":[0.9999014,0.00003573999,0.00001595465,0.000005110111,0.000009030404,0.00003270504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.006160897,0.0005871535,0.01416765,0.0008288702,0.0001867657,0.06021195,0.0003799615,0.001729832,0.05919046,0.003049832,0.01099509,0.8425115],"study_design_scores_gemma":[0.00535694,0.03712237,0.08823127,0.002168305,0.001409772,0.3149987,0.0006385847,0.01046145,0.1360242,0.005043781,0.3984165,0.0001281926],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7001427,0.2401474,0.005797553,0.02575075,0.001767362,0.0002252322,0.0005806467,0.0003042885,0.02528417],"genre_scores_gemma":[0.9465572,0.04485041,0.002561485,0.001742497,0.0005,0.00006968986,0.0002658312,0.00001573339,0.003437131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007213503,"threshold_uncertainty_score":0.002620518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02108863169955378,"score_gpt":0.3181782572892266,"score_spread":0.2970896255896728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}