{"id":"W4394622229","doi":"10.1212/wnl-.0000000000205578","title":"A Randomized, Double-blind, Phase 3 Study of Vorasidenib Versus Placebo in Patients with Mutant IDH1/2 Diffuse Glioma (INDIGO): Analysis of Health-related Quality of Life, Neurocognition and Seizures (PL5.003)","year":2024,"lang":"en","type":"article","venue":"Neurology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Glioma; Placebo; Indigo; IDH1; Medicine; Double blind; Mutant; Quality of life (healthcare); Internal medicine; Oncology; Biology; Pathology; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00113815,0.001675475,0.002906403,0.0005341722,0.0004241884,0.0009787673,0.0009396609,0.001571753,0.006886601],"category_scores_gemma":[0.001086495,0.0006226594,0.001790479,0.0004992352,0.001185047,0.001033382,0.0003622699,0.003154449,0.001106549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007783737,"about_ca_system_score_gemma":0.001154935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217014,"about_ca_topic_score_gemma":0.003317705,"domain_scores_codex":[0.9996043,0.000201278,0.00002048852,0.00007245906,0.00002926282,0.00007224708],"domain_scores_gemma":[0.9994456,0.0001501805,0.0001113507,0.00004530497,0.00003683461,0.0002107022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9805014,0.005594101,0.000264047,0.0003884248,0.0007357228,0.0000271022,0.00003276368,0.000281919,0.002213986,0.0001032277,0.0006867923,0.009170494],"study_design_scores_gemma":[0.9642379,0.03397545,0.0007153456,0.0000136878,0.0001949362,0.00001766271,0.00001367856,0.000248512,0.0001774833,0.0001042049,0.0002923619,0.000008750416],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979425,0.006206044,0.001187051,0.0009789073,0.0008895277,0.005717731,0.002125052,0.0002959455,0.003174736],"genre_scores_gemma":[0.9834743,0.002751452,0.001818773,0.001567617,0.0003564716,0.005362611,0.001521644,0.00003913956,0.00310803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006886601,"threshold_uncertainty_score":0.02303797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04768843526906563,"score_gpt":0.3462705808013643,"score_spread":0.2985821455322987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}