{"id":"W4394626300","doi":"10.1007/978-3-031-41777-1_3","title":"Genetic Association Studies and Next Generation Sequencing in Stroke: Methods","year":2024,"lang":"en","type":"book-chapter","venue":"","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Association (psychology); DNA sequencing; Stroke (engine); Genetic association; Computational biology; Medicine; Computer science; Biology; Genetics; Psychology; Engineering; Genotype; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006215891,0.001016915,0.0009725244,0.001494639,0.0002755259,0.001850856,0.001631569,0.001858742,0.01339865],"category_scores_gemma":[0.006564342,0.0008293742,0.000700994,0.001615345,0.001357261,0.002234082,0.001291279,0.002450222,0.009300913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006537532,"about_ca_system_score_gemma":0.001190527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001053635,"about_ca_topic_score_gemma":0.003224419,"domain_scores_codex":[0.9982702,0.0008569643,0.00009253167,0.0002318808,0.0005088713,0.00003948816],"domain_scores_gemma":[0.9961778,0.003236358,0.00008572858,0.0002008961,0.0002289713,0.00007026539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005655366,0.00005422739,0.000836194,0.001249754,0.0001401584,0.0001732357,0.0001281024,0.001892303,0.002007141,0.09338696,0.2137302,0.6863452],"study_design_scores_gemma":[0.00003676688,0.00007115262,0.001818143,0.0008550202,0.0001015144,0.001895817,0.00007672382,0.004353238,0.001873206,0.2025168,0.7863232,0.00007831873],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.001004195,0.2108773,0.711799,0.0191099,0.006618011,0.0002228152,0.001559649,0.001309875,0.04749926],"genre_scores_gemma":[0.01015528,0.1929329,0.6354057,0.01879485,0.006995963,0.001141122,0.001311363,0.001011728,0.1322511],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.01339865,"threshold_uncertainty_score":0.04482293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09712725449390973,"score_gpt":0.3549851566265886,"score_spread":0.2578579021326789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}