{"id":"W4394632688","doi":"10.3389/fnins.2024.1355695","title":"Multi-pathological contributions toward atrophy patterns in the Alzheimer’s disease continuum","year":2024,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Wake Forest School of Medicine; Yale University; University of California, San Diego; NYU Langone Medical Center; Jewish General Hospital; University of Rochester; Northwestern University; York University; University of South Florida; Ohio State University; Rush University; University of Texas Southwestern Medical Center; Vanderbilt University Medical Center; Georgetown University; Medical School, University of Michigan; University of Pittsburgh; University of California, Los Angeles; Johns Hopkins University; Houston Methodist Research Institute; Emory University; Cleveland Clinic; University of Pennsylvania; Vanderbilt University","keywords":"Atrophy; Pathological; Psychology; Neurodegeneration; Dementia; Pathology; Neuroscience; Brain size; Alzheimer's disease; Disease; Cardiology; Internal medicine; Medicine; Magnetic resonance imaging; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002641501,0.0004333561,0.0005299172,0.00204663,0.0005253457,0.001165736,0.0004903126,0.0003787933,0.002025159],"category_scores_gemma":[0.006006829,0.0002172225,0.0006228609,0.001168817,0.001101445,0.0008689882,0.001465955,0.0004228149,0.0002083359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004881474,"about_ca_system_score_gemma":0.0003121697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00273391,"about_ca_topic_score_gemma":0.002133022,"domain_scores_codex":[0.9988344,0.0005016561,0.0001073573,0.0002628042,0.0001998056,0.00009391022],"domain_scores_gemma":[0.9954091,0.001596486,0.001751778,0.0005233002,0.0003511528,0.0003681568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000207527,0.00003132102,0.9929455,0.00002332772,0.0001521695,0.00009057741,0.0002176323,0.001131722,0.0006481532,0.0002447921,0.00006002987,0.004247139],"study_design_scores_gemma":[0.000007364784,0.00007439176,0.9938034,0.00001070004,0.00003714103,0.0004155678,0.0001979896,0.002996387,0.0001514294,0.002184975,0.0001125686,0.00000809699],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979035,0.00020753,0.001108475,0.00005698491,0.000001759247,0.00001291487,0.0002060764,0.00001861074,0.0004841298],"genre_scores_gemma":[0.9992651,0.00003184044,0.0005086993,0.00000721389,0.0000049288,0.000006830052,0.000132214,0.00000267057,0.00004045825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00273391,"threshold_uncertainty_score":0.01396972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04632619255480486,"score_gpt":0.3580565723523044,"score_spread":0.3117303797974996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}