{"id":"W4394678783","doi":"10.21203/rs.3.rs-4083598/v1","title":"Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Nutrition, Genetics, and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Cancer Institute; Faculty of Medicine and Health, University of Sydney; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; Cancer Council Victoria; Norwegian Institute of Public Health; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Junta de Castilla y León; Génome Québec; Conseil Régional des Pays de la Loire; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Xarxa de Bancs de Tumors de Catalunya; Xunta de Galicia; University of South Florida; Helse Midt-Norge; Vetenskapsrådet; Mutuelle Générale de l'Education Nationale; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; Cancerfonden; Medizinische Universität Graz; Institut Gustave-Roussy; Grantová Agentura České Republiky; Imperial College London; Generalitat de Catalunya; Food Standards Agency; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Marshfield Clinic Research Foundation; Norges Teknisk-Naturvitenskapelige Universitet; National Health and Medical Research Council; Norske Kvinners Sanitetsforening; Norges Forskningsråd; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; Florida Department of Health; Damon Runyon Cancer Research Foundation; Karl-Franzens-Universität Graz; Univerzita Karlova v Praze; McGill University; Victorian Cancer Agency; Memorial Sloan-Kettering Cancer Center; Johns Hopkins University; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Association Anne de Bretagne Genetique; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Fred Hutchinson Cancer Research Center; Wageningen University and Research; Cancer Research UK; American Cancer Society; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Hormone; Colorectal cancer; Oncology; Medicine; Randomization; Internal medicine; Biology; Randomized controlled trial; Cancer; Gene; Genetics; Genotype; Genetic variants","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01012399,0.0007250611,0.001220053,0.0005804932,0.0003969145,0.0006690801,0.0006340741,0.001004688,0.002666241],"category_scores_gemma":[0.02479743,0.0005037863,0.001494357,0.0008753297,0.0005925518,0.0003620014,0.0004242107,0.0005267953,0.0002637455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002965186,"about_ca_system_score_gemma":0.0005017512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002270524,"about_ca_topic_score_gemma":0.001109045,"domain_scores_codex":[0.9898583,0.007481831,0.0004645397,0.001295301,0.0006364492,0.0002634755],"domain_scores_gemma":[0.9922028,0.00448608,0.0009322245,0.001943251,0.0002611128,0.0001744142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08632865,0.001431718,0.7866195,0.0007301553,0.02091907,0.004080667,0.001091957,0.003993474,0.0173075,0.01187094,0.005984453,0.05964187],"study_design_scores_gemma":[0.04456101,0.02563117,0.7418595,0.0003327709,0.02955339,0.01608544,0.0007306313,0.08309647,0.007631192,0.0309984,0.01904317,0.0004769017],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691696,0.00163343,0.02535338,0.0005519508,0.0001666777,0.0004918151,0.0009958192,0.0002012817,0.001435967],"genre_scores_gemma":[0.9901004,0.0002157265,0.008033189,0.0002329455,0.00005615179,0.000281764,0.0003673575,0.00003704899,0.0006754357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01012399,"threshold_uncertainty_score":0.05354148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332557321774951,"score_gpt":0.3392867695676187,"score_spread":0.3259611963498692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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