{"id":"W4394682820","doi":"10.35534/sbe.2024.10002","title":"Bio-Based Production of Uroporphyrin in Escherichia coli","year":2024,"lang":"en","type":"article","venue":"Synthetic biology and engineering","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Escherichia coli; Microbiology; Chemistry; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478133,0.00008773833,0.0001020408,0.00008053883,0.00001073751,0.000004235575,0.00004684611,0.0001058887,0.000006936468],"category_scores_gemma":[0.00006089314,0.00007965284,0.00002936746,0.0001040819,0.00006859837,0.000002165419,0.00002155147,0.00006530309,0.00000176768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002531237,"about_ca_system_score_gemma":0.0000241536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001206347,"about_ca_topic_score_gemma":0.000003834271,"domain_scores_codex":[0.9995031,0.00001914195,0.000118083,0.000210662,0.00002121475,0.0001277353],"domain_scores_gemma":[0.9998318,0.0000100915,0.00001307938,0.0001121043,0.000008813548,0.00002410999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000177566,0.00001866051,0.001969368,0.0001001079,0.0000151288,0.000001235415,0.00002018739,0.0007707971,0.9934169,0.001281528,0.0000373616,0.002350977],"study_design_scores_gemma":[0.0005093586,0.0002358785,0.02615449,0.0001659075,0.00004073246,0.00001603532,0.00006958435,0.007382118,0.9036736,0.0005147816,0.06078599,0.0004514591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904408,0.006643196,0.002140057,0.0001332553,0.0004005668,0.0000698481,0.000004501409,0.00001867757,0.0001490824],"genre_scores_gemma":[0.9988855,0.0002806662,0.0006828251,0.00001733693,0.00005670983,0.00001307813,0.00001644504,0.00001045475,0.00003695682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08974322,"threshold_uncertainty_score":0.3248149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004108888297737915,"score_gpt":0.212724279805074,"score_spread":0.2086153915073361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}