{"id":"W4394684270","doi":"10.1080/15548627.2024.2340399","title":"Mitochondrial import stress and PINK1-mediated mitophagy: the role of the PINK1-TOMM-TIMM23 supercomplex","year":2024,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Structural Genomics Consortium; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Parkinson Canada; Michael J. Fox Foundation for Parkinson's Research","keywords":"PINK1; Mitophagy; Parkin; Biology; Cell biology; Mitochondrion; ATP–ADP translocase; DNAJA3; Translocase; Inner mitochondrial membrane; Ubiquitin ligase; Biochemistry; mitochondrial fusion; Mitochondrial DNA; Ubiquitin; Parkinson's disease; Autophagy; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002070558,0.0003165247,0.0001889619,0.0003911199,0.0002982054,0.0005929029,0.0001837367,0.0002747689,0.0005235468],"category_scores_gemma":[0.0001513474,0.0001179939,0.0001414138,0.0002393464,0.0006415527,0.0004854406,0.0005074416,0.0003770041,0.0001611898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005958564,"about_ca_system_score_gemma":0.0002296249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004945709,"about_ca_topic_score_gemma":0.0004587839,"domain_scores_codex":[0.999911,0.00001802314,0.000007549065,0.00002274539,0.0000258961,0.00001494359],"domain_scores_gemma":[0.999926,0.000008259669,0.00002800912,0.000006914176,0.000007437116,0.00002347024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008285111,0.00006612916,0.00392225,0.000272583,0.00004124074,0.001397151,0.0001952549,0.0005577353,0.9757613,0.002768717,0.0003786731,0.01381031],"study_design_scores_gemma":[0.00004662828,0.0004568941,0.04108484,0.00003789572,0.00007568314,0.008055311,0.0002628393,0.004388351,0.9306222,0.003209954,0.01172302,0.00003646858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755662,0.01940742,0.002337247,0.000679913,0.00005302047,0.00002182182,0.0001321298,0.00006339357,0.001738875],"genre_scores_gemma":[0.9946029,0.003726102,0.0005899956,0.00006094588,0.00001960279,0.000009643554,0.00006710143,0.000007306636,0.0009165733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005958564,"threshold_uncertainty_score":0.004323244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006430581457789049,"score_gpt":0.2465927709560109,"score_spread":0.2401621894982219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}