{"id":"W4394687910","doi":"10.1002/ueg2.12547","title":"Difficult‐to‐treat inflammatory bowel disease: Effectiveness and safety of 4th and 5th lines of treatment","year":2024,"lang":"en","type":"article","venue":"United European Gastroenterology Journal","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Vedolizumab; Ustekinumab; Inflammatory bowel disease; Internal medicine; Persistence (discontinuity); Ulcerative colitis; Crohn's disease; Gastroenterology; Confidence interval; Disease; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003498383,0.0002126105,0.0001589955,0.0002422872,0.0000791266,0.0000245809,0.0001116159,0.00004160939,0.000007544417],"category_scores_gemma":[0.00007687287,0.0001691998,0.00008693133,0.00005275479,0.0002181736,0.000008498267,0.0001292648,0.0001235278,0.00000238766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000254962,"about_ca_system_score_gemma":0.00005653949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001430788,"about_ca_topic_score_gemma":0.000003698198,"domain_scores_codex":[0.9983723,0.0007212623,0.0003362674,0.0002657639,0.0000791112,0.0002253208],"domain_scores_gemma":[0.9992265,0.00003068706,0.0001041767,0.0001966884,0.0001361304,0.0003058592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006687604,0.0001313698,0.8475452,0.0003829264,0.0003663406,0.0008607262,0.0002239083,0.0009589783,0.1413776,0.00006045437,0.0002456857,0.001159197],"study_design_scores_gemma":[0.001604936,0.001226143,0.9941034,0.0002086866,0.0001555957,0.0002683947,0.00004590929,0.0001175715,0.00128486,0.000006378064,0.0008833996,0.00009478147],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982215,0.0006634672,0.0005461273,0.00006255931,0.0001122892,0.000185599,0.0001135104,0.00001304501,0.00008190213],"genre_scores_gemma":[0.998903,0.0006119842,0.0000949423,0.00007723252,0.0001564308,0.000003737146,0.00005034582,0.00003577186,0.00006658443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1465582,"threshold_uncertainty_score":0.6899767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005575883359396798,"score_gpt":0.2293799060732406,"score_spread":0.2238040227138438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}