{"id":"W4394687910","doi":"10.1002/ueg2.12547","title":"Difficult‐to‐treat inflammatory bowel disease: Effectiveness and safety of 4th and 5th lines of treatment","year":2024,"lang":"en","type":"article","venue":"United European Gastroenterology Journal","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Vedolizumab; Ustekinumab; Inflammatory bowel disease; Internal medicine; Persistence (discontinuity); Ulcerative colitis; Crohn's disease; Gastroenterology; Confidence interval; Disease; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002865699,0.0001462422,0.000757092,0.0004137965,0.000176774,0.000547015,0.0001926547,0.0004218919,0.001245758],"category_scores_gemma":[0.00511809,0.00005077359,0.0007335774,0.0002971899,0.0002871761,0.0006097415,0.0002703894,0.0003750487,0.0001112339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003663511,"about_ca_system_score_gemma":0.0002178221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001728222,"about_ca_topic_score_gemma":0.0002416435,"domain_scores_codex":[0.9979379,0.0009545031,0.0002510304,0.0002050077,0.0005455475,0.0001060338],"domain_scores_gemma":[0.992972,0.002498988,0.003656658,0.0002533307,0.0002846259,0.0003344187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02876838,0.001256684,0.6169298,0.001244875,0.002292785,0.0002756972,0.0002385899,0.001154542,0.003696657,0.0002432232,0.0005988267,0.3433],"study_design_scores_gemma":[0.001679132,0.03993521,0.944723,0.0006107048,0.001579047,0.002185438,0.0002022641,0.002607495,0.002892412,0.000331112,0.003221626,0.00003259959],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719786,0.0259638,0.0003244176,0.0002477533,0.00002668756,0.00003484061,0.000162847,0.000008783057,0.001252319],"genre_scores_gemma":[0.9977838,0.001578917,0.0002050731,0.00008311605,0.00007240543,0.00001464856,0.00015808,0.000002267336,0.0001016767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002865699,"threshold_uncertainty_score":0.01515543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005575883359396798,"score_gpt":0.2293799060732406,"score_spread":0.2238040227138438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}