{"id":"W4394688780","doi":"10.1101/2024.04.09.588654","title":"Structure of Calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; British Columbia Knowledge Development Fund; Michael Smith Health Research BC","keywords":"Calcineurin; Dual (grammatical number); Interface (matter); Computer science; Parallel computing; Medicine; Art; Internal medicine; Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008629829,0.0003377782,0.0002433284,0.0001685079,0.0005006249,0.0003516427,0.0005865127,0.0005995136,0.003621216],"category_scores_gemma":[0.0001795165,0.0001583408,0.0002591864,0.0002442244,0.0002671523,0.0003179625,0.0002822156,0.0008710723,0.0004093372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008758812,"about_ca_system_score_gemma":0.0003124629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004992971,"about_ca_topic_score_gemma":0.003077803,"domain_scores_codex":[0.9999493,0.000004670473,0.000001892999,0.00001186339,0.00002074963,0.00001149695],"domain_scores_gemma":[0.9999391,0.00001348838,0.00001583206,0.000004159587,0.000008062524,0.00001933688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001347792,0.0002854539,0.005638623,0.000363487,0.000121685,0.003529048,0.0004522022,0.009349652,0.9651449,0.002935564,0.003289453,0.007542192],"study_design_scores_gemma":[0.0005994469,0.0008780239,0.1179285,0.0001861905,0.0001752645,0.005070771,0.0008997401,0.2390199,0.6032686,0.002524144,0.02927756,0.0001718473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994272,0.0005992259,0.001885247,0.0002755129,0.00003196412,0.000009361253,0.000369056,0.0001840566,0.002373627],"genre_scores_gemma":[0.9908285,0.0004978357,0.002645565,0.00007136702,0.000009295458,0.000008795728,0.002176794,0.00005949618,0.003702339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004992971,"threshold_uncertainty_score":0.01211417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009922076417098016,"score_gpt":0.2454235383866038,"score_spread":0.2355014619695057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}