{"id":"W4394691194","doi":"10.1093/pnasnexus/pgae153","title":"Probing the CRL4DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons","year":2024,"lang":"en","type":"article","venue":"PNAS Nexus","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Janssen Canada; Genentech; Janssen Biotech; Innovative Medicines Initiative; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; Takeda Oncology; Boehringer Ingelheim; McGill University; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Degron; Biology; Protein subunit; Ubiquitin ligase; Ubiquitin-Protein Ligases; Cell biology; Plasma protein binding; Ubiquitin; Mutagenesis; Biochemistry; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001760923,0.000235322,0.0001767172,0.0001043178,0.0003168293,0.0002307926,0.0003384642,0.0003555316,0.0009777085],"category_scores_gemma":[0.0001927908,0.0001249962,0.000190709,0.0001280337,0.0002113384,0.0002186949,0.0002361264,0.0005663729,0.0002744395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009064552,"about_ca_system_score_gemma":0.0001846146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002951757,"about_ca_topic_score_gemma":0.003117935,"domain_scores_codex":[0.9998704,0.00001859659,0.000005321614,0.00003569294,0.00003595875,0.00003387616],"domain_scores_gemma":[0.9999201,0.00001980624,0.00001944542,0.000006237638,0.00001087081,0.00002350529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007007602,0.0000197131,0.0002747876,0.00002116023,0.000006111932,0.00004934834,0.00002367551,0.000201052,0.9987587,0.00009740548,0.00004945547,0.0004285494],"study_design_scores_gemma":[0.000008227337,0.00005135711,0.002948154,0.000003475438,0.00000613654,0.0001034764,0.00005669537,0.003628459,0.9920154,0.00003356025,0.001139879,0.000005232997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964971,0.0003180596,0.002157748,0.00007657827,0.000007262931,0.000005370161,0.0001062584,0.00002049738,0.0008111316],"genre_scores_gemma":[0.9956766,0.0002035595,0.002295813,0.00007087306,0.00000276282,0.00001176041,0.0002867328,0.00001311042,0.001438802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002951757,"threshold_uncertainty_score":0.006576777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536071666177837,"score_gpt":0.2587380518075943,"score_spread":0.2433773351458159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}