{"id":"W4394691194","doi":"10.1093/pnasnexus/pgae153","title":"Probing the CRL4DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons","year":2024,"lang":"en","type":"article","venue":"PNAS Nexus","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Janssen Canada; Genentech; Janssen Biotech; Innovative Medicines Initiative; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; Takeda Oncology; Boehringer Ingelheim; McGill University; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Degron; Biology; Protein subunit; Ubiquitin ligase; Ubiquitin-Protein Ligases; Cell biology; Plasma protein binding; Ubiquitin; Mutagenesis; Biochemistry; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009194516,0.0001151111,0.00006705037,0.00002487399,0.0001381624,0.0001231584,0.00009813107,0.00004541088,0.00003698738],"category_scores_gemma":[0.00001777699,0.00007284263,0.00003708639,0.00006764313,0.00009110306,0.000007463837,0.00008497407,0.0001500493,0.00002511687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007937007,"about_ca_system_score_gemma":0.00005974416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001671836,"about_ca_topic_score_gemma":0.0000650274,"domain_scores_codex":[0.9993957,0.00003787217,0.00008829109,0.0002399114,0.00006582662,0.0001723716],"domain_scores_gemma":[0.9996846,0.00002494677,0.00002092215,0.0001936183,0.00002260704,0.00005331187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002223576,0.0001281016,0.001642913,0.0003250586,0.000326344,0.0002328027,0.002826458,0.00005427094,0.8947964,0.004596132,0.009147216,0.085702],"study_design_scores_gemma":[0.0005328084,0.0007300624,0.002255783,0.0002677267,0.0001386167,0.001982646,0.000832771,0.001483052,0.325831,0.0007835876,0.6646318,0.0005301452],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657497,0.0039381,0.003367898,0.00158228,0.0003436235,0.0003851629,0.00003438209,0.0000652106,0.02453364],"genre_scores_gemma":[0.9955304,0.0000508626,0.0002622766,0.0001868901,0.0003032716,0.00007044655,0.00002807391,0.00002050766,0.003547292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6554846,"threshold_uncertainty_score":0.2970436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536071666177837,"score_gpt":0.2587380518075943,"score_spread":0.2433773351458159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}