{"id":"W4394691928","doi":"10.1080/07435800.2024.2337758","title":"Comparison of in vitro Toxicities of 8-Prenylnaringenin, Tartrazine and 17β-Estradiol, Representatives of Natural and Synthetic Estrogens, in Rat and Human Hepatoma Cell Lines","year":2024,"lang":"en","type":"article","venue":"Endocrine Research","topic":"Hops Chemistry and Applications","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Xenoestrogen; Phytoestrogens; Cytotoxicity; Estrogen; Genotoxicity; Micronucleus test; In vitro; Cell growth; Cell culture; Biology; Chemistry; Pharmacology; Endocrinology; Toxicity; Internal medicine; Biochemistry; Estrogen receptor; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002430794,0.0002874778,0.0001792321,0.0003857051,0.0001190779,0.0001325958,0.0001100814,0.0002345105,0.001398435],"category_scores_gemma":[0.0002318785,0.0001128866,0.0002053692,0.000282812,0.0001949624,0.0001557728,0.0001689433,0.000228818,0.0002231941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001762951,"about_ca_system_score_gemma":0.0001822216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001099008,"about_ca_topic_score_gemma":0.001575587,"domain_scores_codex":[0.9998276,0.00005737038,0.00002621877,0.00002926433,0.00003850339,0.00002099339],"domain_scores_gemma":[0.9997314,0.00012403,0.00003995061,0.00002446946,0.00004823313,0.00003192942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001017252,0.000133036,0.002858239,0.000215899,0.00004356331,0.0001268399,0.00008890984,0.0004102147,0.9910622,0.00008642622,0.00005212861,0.003905327],"study_design_scores_gemma":[0.00004223715,0.00471088,0.01547169,0.00001420586,0.00006902339,0.0005391316,0.0001178528,0.0004492714,0.9765314,0.00005580581,0.001991229,0.000007238947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931156,0.004050033,0.0007285518,0.00003873313,0.00001964566,0.00002833522,0.0004134862,0.00001493788,0.001590617],"genre_scores_gemma":[0.992286,0.003105122,0.001018717,0.00003112463,0.00001359209,0.00003517769,0.001037044,0.000006261584,0.00246691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398435,"threshold_uncertainty_score":0.004678249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1630599049969714,"score_gpt":0.5410384101963496,"score_spread":0.3779785051993781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}