{"id":"W4394691928","doi":"10.1080/07435800.2024.2337758","title":"Comparison of in vitro Toxicities of 8-Prenylnaringenin, Tartrazine and 17β-Estradiol, Representatives of Natural and Synthetic Estrogens, in Rat and Human Hepatoma Cell Lines","year":2024,"lang":"en","type":"article","venue":"Endocrine Research","topic":"Hops Chemistry and Applications","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Xenoestrogen; Phytoestrogens; Cytotoxicity; Estrogen; Genotoxicity; Micronucleus test; In vitro; Cell growth; Cell culture; Biology; Chemistry; Pharmacology; Endocrinology; Toxicity; Internal medicine; Biochemistry; Estrogen receptor; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004621248,0.0001096452,0.00032366,0.0002259034,0.00005336171,0.00001017798,0.0001061952,0.00006566606,0.00003520792],"category_scores_gemma":[0.00007196239,0.0001043503,0.00002579715,0.0003049166,0.000812759,0.00005949033,0.0001421181,0.0006456538,3.965827e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001390726,"about_ca_system_score_gemma":0.00003788053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001357071,"about_ca_topic_score_gemma":0.00004510001,"domain_scores_codex":[0.9987103,0.0002573134,0.0003941141,0.0002582702,0.0001354686,0.0002445097],"domain_scores_gemma":[0.9987423,0.00095321,0.00005082181,0.0001221332,0.00005903143,0.00007254942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001700432,0.0002098782,0.09898572,0.0008334657,0.00003014086,0.00002811717,0.00123741,0.00002025459,0.8959749,0.0006299504,0.0001141066,0.001765997],"study_design_scores_gemma":[0.0005808199,0.00009976058,0.005312575,0.00007412042,0.00001584906,0.00002369228,0.001108919,0.002673049,0.9889297,0.0003093679,0.0007981054,0.00007407953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840923,0.01476485,0.000001196407,0.0002956744,0.00002481225,0.0002294669,0.00004935524,0.000009356359,0.0005330131],"genre_scores_gemma":[0.9984578,0.001098069,0.0001352798,0.0000034098,0.00002939469,0.0000368647,0.00001561784,0.000009374208,0.0002141121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09367315,"threshold_uncertainty_score":0.4255283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1630599049969714,"score_gpt":0.5410384101963496,"score_spread":0.3779785051993781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}