{"id":"W4394694541","doi":"10.1101/2024.04.06.588414","title":"CAR Tregs mediate linked suppression and infectious tolerance in islet transplantation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"BC Children's Hospital; National Institutes of Health; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Islet; Transplantation; Immunology; Medicine; Internal medicine; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002963685,0.0003234198,0.000235902,0.0001970379,0.0002304489,0.0004889908,0.0001865494,0.000423456,0.008808011],"category_scores_gemma":[0.0002449511,0.0001279983,0.0001995795,0.00006982568,0.0001432211,0.0002379806,0.0002751025,0.0004909299,0.003034263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001674059,"about_ca_system_score_gemma":0.0001667493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001331907,"about_ca_topic_score_gemma":0.0001603153,"domain_scores_codex":[0.9999065,0.00001372825,0.000004768267,0.0000133642,0.00004633595,0.00001517427],"domain_scores_gemma":[0.9999278,0.00001862543,0.000008601582,0.000007207089,0.00001399304,0.00002391804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005482456,0.0001701371,0.0004806427,0.0002092806,0.00001983373,0.00094411,0.00009081448,0.0006611631,0.9225852,0.008106997,0.03139376,0.03478982],"study_design_scores_gemma":[0.0002413917,0.0004648484,0.00390489,0.00005661576,0.00004467823,0.00159072,0.00009079621,0.008882107,0.8188999,0.004023219,0.1617726,0.00002817893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8172075,0.01172553,0.05013484,0.008564068,0.01741316,0.0001957009,0.001574647,0.003055239,0.09012931],"genre_scores_gemma":[0.8428785,0.00405967,0.007582954,0.002016682,0.002033802,0.00009346697,0.001208301,0.0005023238,0.1396243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008808011,"threshold_uncertainty_score":0.02946573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009819851771527693,"score_gpt":0.2270375996269215,"score_spread":0.2172177478553938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}